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508120 GR113808 - CAS 144625-51-4 - Calbiochem

GR113808 - CAS 144625-51-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-HT₄ Serotonin Receptor Antagonist, GR113808, GR 113808, GR-113808

Primary Target: 5-HT₄
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
144625-51-4C₁₉H₂₇N₃O₄S
Description
Overview

This product has been discontinued.



A potent and selective antagonist of the serotonin 5-HT4 receptor (pki = 9.3-10.3). GR113808 is commonly used in brain and peripheral in vitro and in vivo in striatum studies (Guinea pig IC50 = 113 nM, rat brain membrane Kd = 0.4-1 nM) and in cAMP response in CHO and C6 glial cells (EC50 = 79-81 nM).
Catalogue Number508120
Brand Family Calbiochem®
Synonyms5-HT₄ Serotonin Receptor Antagonist, GR113808, GR 113808, GR-113808
References
ReferencesJohnson, D. E. et al. 2012. J. Pharmacol. Exp. Ther. 112, 681.
Mine, Y. et al. 1997. J. Pharmacol. Exp. Ther. 283, 1000.
Gale, J. D. et al. 1994. Br. J. Pharmacol. 111, 332.
Product Information
CAS number144625-51-4
FormOff-white solid
Hill FormulaC₁₉H₂₇N₃O₄S
Chemical formulaC₁₉H₂₇N₃O₄S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target5-HT₄
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
508120 0

Documentation

GR113808 - CAS 144625-51-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Johnson, D. E. et al. 2012. J. Pharmacol. Exp. Ther. 112, 681.
Mine, Y. et al. 1997. J. Pharmacol. Exp. Ther. 283, 1000.
Gale, J. D. et al. 1994. Br. J. Pharmacol. 111, 332.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-October-2013 JSW
Synonyms5-HT₄ Serotonin Receptor Antagonist, GR113808, GR 113808, GR-113808
DescriptionA potent and selective antagonist of the serotonin 5-HT4 receptor (pki = 9.3-10.3). GR113808 is commonly used in brain and peripheral in vitro and in vivo in striatum studies (Guinea pig IC50 = 113 nM, rat brain membrane Kd = 0.4-1 nM) and in cAMP response in CHO and C6 glial cells (EC50 = 79-81 nM).
FormOff-white solid
CAS number144625-51-4
Chemical formulaC₁₉H₂₇N₃O₄S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mM) or Ethanol (10 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesJohnson, D. E. et al. 2012. J. Pharmacol. Exp. Ther. 112, 681.
Mine, Y. et al. 1997. J. Pharmacol. Exp. Ther. 283, 1000.
Gale, J. D. et al. 1994. Br. J. Pharmacol. 111, 332.