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371822 GPR120 Agonist III - Calbiochem

The GPR120 Agonist III controls the biological activity of GPR120. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

GPR120 Agonist III - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(4-((4-Fluoro-4ʹ-methyl-(1,1ʹ-biphenyl)-2-yl)methoxy)-phenyl)propanoic acid

371822
  
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Overview

Replacement Information
Description
OverviewA membrane-permeant biphenyl-methoxy-phenylpropanoate compound that acts as an active-site targeting, selective, potent agonist of G-protein coupled receptor 120/GPR120 (EC50 of β-arrestin 2 recruitment = 17 nM and 44 nM for mGPR120 and hGPR120, respectively; EC50 of Ca++ mobilization = 96 nM for hGPR120). Exhibits much reduced potency toward free fatty acid receptor 1/FFA1/GPR40 (EC50 of β-arrestin 2 recruitment = 64.6 µM) and no activity toward short chain FFA receptors FFA2/GPR43 and FFA3/GPR41.
Catalogue Number371822
Brand Family Calbiochem®
Synonyms3-(4-((4-Fluoro-4ʹ-methyl-(1,1ʹ-biphenyl)-2-yl)methoxy)-phenyl)propanoic acid
References
ReferencesShimpukade, B., et al. 2012. J. Med. Chem. 55, 4511.
Product Information
FormWhite powder
Hill FormulaC₂₃H₂₁FO₃
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetG-protein coupled receptor 120
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
371822 0

Documentation

GPR120 Agonist III - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

GPR120 Agonist III - Calbiochem Certificates of Analysis

TitleLot Number
371822

References

Reference overview
Shimpukade, B., et al. 2012. J. Med. Chem. 55, 4511.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision02-October-2012 JSW
Synonyms3-(4-((4-Fluoro-4ʹ-methyl-(1,1ʹ-biphenyl)-2-yl)methoxy)-phenyl)propanoic acid
DescriptionA membrane-permeant biphenyl-methoxy-phenylpropanoate compound that acts as an active-site targeting, selective, potent agonist of G-protein coupled receptor 120/GPR120 (EC50 of β-arrestin 2 recruitment = 17 nM and 44 nM for mGPR120 and hGPR120, respectively; EC50 of Ca++ mobilization = 96 nM for hGPR120). Exhibits much reduced potency toward free fatty acid receptor 1/FFA1/GPR40 (EC50 of β-arrestin 2 recruitment = 64.6 µM) and no activity toward short chain FFA receptors FFA2/GPR43 and FFA3/GPR41.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesShimpukade, B., et al. 2012. J. Med. Chem. 55, 4511.