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345885 GGTI-2147 - CAS 191102-87-1 - Calbiochem

345885
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Overview

Key Spec Table

CAS #Empirical Formula
191102-87-1C₂₈H₃₀N₄O₃

Products

Catalogue NumberPackaging Qty/Pack
345885-250UG Plastic ampoule 250 μg
Description
OverviewA cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I). Blocks the geranyl-geranylation of Rap1A with an IC50 value that is over 60-fold lower than that required to disrupt the farnesylation of H-Ras (IC50 = 500 nM for Rap1A versus IC50 > 30 µM for H-Ras).
Catalogue Number345885
Brand Family Calbiochem®
Synonyms4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester
References
ReferencesBernot, D., et al. 2003. J. Cardiovasc. Pharmacol. 41, 316.
Vasudevan, A., et al. 1999. J. Med. Chem. 42, 1333.
Product Information
CAS number191102-87-1
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₈H₃₀N₄O₃
Chemical formulaC₂₈H₃₀N₄O₃
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetGGTase-I
Primary Target IC<sub>50</sub>500 nM in blocking the geranyl-geranylation of Rap1A
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
345885-250UG 04055977214529