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508048 Filastatin - Calbiochem

Filastatin - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(3-Chloro-4-methylbenzoyl)-4-(4-nitrophenyl)piperazine, (3-Chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone

508048
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₈H₁₈ClN₃O₃
Description
OverviewA cell-permeable, nontoxic benzoyl-nitrophenylpiperazine compound with anti-fungal properties. Prevents the adhesion of multiple pathogenic Candida species to polystyrene surfaces and human cells (IC50 = 3 µM in A549 cells). Does not affect the viability of human cells even at high concentrations (~250 µM). Also effective, but to slightly lower extent, when added to cells following their adhesion. Keeps cells dispersed in the media and blocks the formation of hyphae (~2.5 µM). Also reported to block the transcriptional induction of the HWP1 promoter and is believed to act downstream of Efg1 transcription factor. Exhibits antifungal activity in a nematode model (C. elegans) and increases the life span of Candida infected worms. Also reported to alter biofilm morphology in a murine model of vulvovaginal candidiasis.
Catalogue Number508048
Brand Family Calbiochem®
Synonyms1-(3-Chloro-4-methylbenzoyl)-4-(4-nitrophenyl)piperazine, (3-Chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone
References
ReferencesFazly, A., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 13594.
Product Information
FormYellow powder
Hill FormulaC₁₈H₁₈ClN₃O₃
Chemical formulaC₁₈H₁₈ClN₃O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
508048 0

Documentation

Filastatin - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Fazly, A., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 13594.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-November-2013 JSW
Synonyms1-(3-Chloro-4-methylbenzoyl)-4-(4-nitrophenyl)piperazine, (3-Chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone
DescriptionA cell-permeable, nontoxic benzoyl-nitrophenylpiperazine compound with anti-fungal properties. Prevents the adhesion of multiple pathogenic Candida species to polystyrene surfaces and human cells (IC50 = 3 µM in A549 cells). Does not affect the viability of human cells even at high concentrations (~250 µM). Also effective, but to slightly lower extent, when added to cells following their adhesion. Keeps cells dispersed in the media and blocks the formation of hyphae (~2.5 µM). Also reported to block the transcriptional induction of the HWP1 promoter and is believed to act downstream of Efg1 transcription factor. Exhibits antifungal activity in a nematode model (C. elegans) and increases the life span of Candida infected worms. Also reported to alter biofilm morphology in a murine model of vulvovaginal candidiasis.
FormYellow powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₈H₁₈ClN₃O₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesFazly, A., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 13594.