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344154 FPT Inhibitor III - Calbiochem

The FPT Inhibitor III controls the biological activity of FPT. This small molecule/inhibitor is primarily used for Cancer applications.

FPT Inhibitor III - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E,E)-[2-Oxo-2-[[(3,7,11-trimethyl-2,6,10-dodecatrienyl)oxy]amino]ethyl]phosphonic Acid, (2,2-Dimethyl-1-oxopropoxy)methyl Ester, Na

Primary Target: FTase
344154
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₃H₃₉NO₇P . Na
Description
Overview

This product has been discontinued.





A cell-permeable prodrug ester form of farnesyltransferase (FTase) inhibitor II (Cat. No. 344152). Also inhibits Ras processing in cells (~100 µM), thereby preventing Ras-mediated transformation. Inhibits C15 and C20 protein prenylation in NIH-3T3 cells.
Catalogue Number344154
Brand Family Calbiochem®
Synonyms(E,E)-[2-Oxo-2-[[(3,7,11-trimethyl-2,6,10-dodecatrienyl)oxy]amino]ethyl]phosphonic Acid, (2,2-Dimethyl-1-oxopropoxy)methyl Ester, Na
References
ReferencesWang, D., et al. 1998. J. Biol. Chem. 273, 33027.
Manne, V., et al. 1995. Drug Development Res. 34, 121.
Product Information
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₂₃H₃₉NO₇P . Na
Chemical formulaC₂₃H₃₉NO₇P . Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetFTase
Primary Target IC<sub>50</sub>~100 µM inhibiting Ras processing in cells, thereby preventing Ras-mediated transformation
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
344154 0

Documentation

FPT Inhibitor III - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

FPT Inhibitor III - Calbiochem Certificates of Analysis

TitleLot Number
344154

References

Reference overview
Wang, D., et al. 1998. J. Biol. Chem. 273, 33027.
Manne, V., et al. 1995. Drug Development Res. 34, 121.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-June-2008 RFH
Synonyms(E,E)-[2-Oxo-2-[[(3,7,11-trimethyl-2,6,10-dodecatrienyl)oxy]amino]ethyl]phosphonic Acid, (2,2-Dimethyl-1-oxopropoxy)methyl Ester, Na
DescriptionA cell-permeable pro-drug of farnesyltransferase (FPT) inhibitor II (Cat. No. 344152). Less active as a farnesyltransferase inhibitor (IC50 = 2.6 µM). Inhibits Ras processing in cells (~100 µM), preventing Ras-mediated transformation.
FormPale yellow solid
Chemical formulaC₂₃H₃₉NO₇P . Na
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityH₂O (50 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Toxicity Standard Handling
ReferencesWang, D., et al. 1998. J. Biol. Chem. 273, 33027.
Manne, V., et al. 1995. Drug Development Res. 34, 121.