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325001 Epothilone B, Synthetic

A structural analog of Epothilone A with similar biological properties.

Epothilone B, Synthetic MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: EpoB

Primary Target: P-glycoprotein-expressing multidrug resistant (MDR) cells
325001
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
152044-54-7C₂₇H₄₁NO₆S
Description
Overview

This product has been discontinued.



A structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells).
Catalogue Number325001
Brand Family Calbiochem®
SynonymsEpoB
References
ReferencesGiannakakou, P., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2904.
Chou, T.-C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 9642.
Kowalski, R.J., et al. 1997. J. Biol. Chem. 272, 2534.
Muhlradt, P.F., and Sasse, F. 1997. Cancer Res. 57, 3344.
Nicolaou, K.C., et al. 1997. Nature 387, 268.
Bollag, D.M., et al. 1995. Cancer Res. 55, 2325.
Product Information
CAS number152044-54-7
ATP CompetitiveN
DeclarationNot available for sale in Germany.
FormWhite to off-white solid
Hill FormulaC₂₇H₄₁NO₆S
Chemical formulaC₂₇H₄₁NO₆S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetP-glycoprotein-expressing multidrug resistant (MDR) cells
Primary Target IC<sub>50</sub>2 nM for MDR CCRF-CEM/VBL100 cells
Purity≥99% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 23/24/25-37/38-41-46-60

Toxic by inhalation, in contact with skin and if swallowed.
Irritating to respiratory system and skin.
Risk of serious damage to eyes.
May cause heritable genetic damage.
May impair fertility.
S PhraseS: 22-26-36/37/39-45

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
325001 0

Documentation

Epothilone B, Synthetic SDS

Title

Safety Data Sheet (SDS) 

Epothilone B, Synthetic Certificates of Analysis

TitleLot Number
325001

References

Reference overview
Giannakakou, P., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2904.
Chou, T.-C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 9642.
Kowalski, R.J., et al. 1997. J. Biol. Chem. 272, 2534.
Muhlradt, P.F., and Sasse, F. 1997. Cancer Res. 57, 3344.
Nicolaou, K.C., et al. 1997. Nature 387, 268.
Bollag, D.M., et al. 1995. Cancer Res. 55, 2325.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-December-2018 JSW
SynonymsEpoB
DescriptionA structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multi drug resistant (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells).
FormWhite to off-white solid
CAS number152044-54-7
Chemical formulaC₂₇H₄₁NO₆S
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
Toxicity Toxic & Carcinogenic / Teratogenic
ReferencesGiannakakou, P., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2904.
Chou, T.-C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 9642.
Kowalski, R.J., et al. 1997. J. Biol. Chem. 272, 2534.
Muhlradt, P.F., and Sasse, F. 1997. Cancer Res. 57, 3344.
Nicolaou, K.C., et al. 1997. Nature 387, 268.
Bollag, D.M., et al. 1995. Cancer Res. 55, 2325.