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324760 Endothall - CAS 145-73-3 - Calbiochem

Endothall - CAS 145-73-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid

Primary Target: PP2A
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
145-73-3C₈H₁₀O₅
Description
Overview

This product has been discontinued.



A cell-permeable, specific inhibitor of protein phosphatase 2A (PP2A, IC50 = 90 nM). Exhibits only a weak effect on PP1 (IC50 = 5 µM). Causes dose- and time-dependent cytostasis at the G2/M phase in hepatocellular carcinoma cell lines.
Catalogue Number324760
Brand Family Calbiochem®
Synonyms7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid
References
ReferencesAyaydin, F., et al. 2000. Plant J. 23, 85.
Thiery, J.P., et al. 1999. Hepatology 29, 1406.
Li, Y.M., et al. 1993. Biochem. Pharmacol. 46, 1435.
Li, Y.M., and Casida, J.E. 1992. Proc. Natl. Acad. Sci. USA 89, 11867.
Product Information
CAS number145-73-3
ATP CompetitiveN
FormWhite solid
Hill FormulaC₈H₁₀O₅
Chemical formulaC₈H₁₀O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPP2A
Primary Target IC<sub>50</sub>90 nM against protein phosphatase 2A (PP2A)
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSRN7875000
Safety Information
R PhraseR: 21-25-36/37/38

Harmful in contact with skin.
Toxic if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
324760 0

Documentation

Endothall - CAS 145-73-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Endothall - CAS 145-73-3 - Calbiochem Certificates of Analysis

TitleLot Number
324760

References

Reference overview
Ayaydin, F., et al. 2000. Plant J. 23, 85.
Thiery, J.P., et al. 1999. Hepatology 29, 1406.
Li, Y.M., et al. 1993. Biochem. Pharmacol. 46, 1435.
Li, Y.M., and Casida, J.E. 1992. Proc. Natl. Acad. Sci. USA 89, 11867.

Brochure

Title
Protein Phosphatases Technical Bulletin
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-June-2008 RFH
Synonyms7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid
DescriptionA specific, cell-permeable inhibitor of protein phosphatase 2A (PP2A)(IC50 = 90 nM). Exhibits only weak inhibitory activity towards protein phosphatase 1 (PP1) (IC50 = 5 µM). Causes dose- and time-dependent cytostasis at the G2/M phase in hepatocellular carcinoma cell lines.
FormWhite solid
CAS number145-73-3
RTECSRN7875000
Chemical formulaC₈H₁₀O₅
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityH₂O (25 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic
ReferencesAyaydin, F., et al. 2000. Plant J. 23, 85.
Thiery, J.P., et al. 1999. Hepatology 29, 1406.
Li, Y.M., et al. 1993. Biochem. Pharmacol. 46, 1435.
Li, Y.M., and Casida, J.E. 1992. Proc. Natl. Acad. Sci. USA 89, 11867.