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328006 ERK Inhibitor - CAS 1049738-54-6 - Calbiochem

The ERK Inhibitor, also referenced under CAS 1049738-54-6, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicat

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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl

Primary Target: ERK
328006
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Overview

Key Spec Table

CAS #Empirical Formula
1049738-54-6C₁₄H₁₆N₂O₃S • HCl

Products

Catalogue NumberPackaging Qty/Pack
328006-5MG Plastic ampoule 5 mg
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Description
OverviewA cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC50 ≤ 25 µM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a KD of ~5 µM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.
Catalogue Number328006
Brand Family Calbiochem®
Synonyms3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl
References
ReferencesHancock, C. N., et al. 2005. J. Med. Chem. 48, 4586.
Product Information
CAS number1049738-54-6
ATP CompetitiveN
FormLight yellow solid
Hill FormulaC₁₄H₁₆N₂O₃S • HCl
Chemical formulaC₁₄H₁₆N₂O₃S • HCl
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetERK
Primary Target IC<sub>50</sub>≤ 25 µM for anti-proliferative properties in HeLa, A549, and SUM-159 tumor cells; KD of ~5 µM for ERK2
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
328006-5MG 04055977196351