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324840 EGFR/ErbB-2/ErbB-4 Inhibitor - CAS 881001-19-0 - Calbiochem

The EGFR/ErbB-2/ErbB-4 Inhibitor, also referenced under CAS 881001-19-0, controls the biological activity of EGFR/ErbB-2/ErbB-4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(4-((3-Chloro-4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)2-butynamide

Primary Target: EGFR/ErbB-2/ErbB-4
324840
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
881001-19-0C₁₇H₁₁ClFN₅O•2.5H₂O
Description
Overview

This product has been discontinued.



A cell-permeable, ATP-binding site-targeting alkynamidopyrimidine compound that acts as a potent and irreversible inhibitor of erbB activities (IC50 = 0.3, 1.1, and 0.5 nM for erbB-1, erbB-2, and erbB-4, respectively). Inhibits EGF- and heregulin-induced erbB autophosphorylation in NIH3T3-erbB-1 and in MDA-MB-453 cells (IC50 = 2.5 and 24 nM, respectively).
Catalogue Number324840
Brand Family Calbiochem®
SynonymsN-(4-((3-Chloro-4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)2-butynamide
References
ReferencesKlutchko, S.R., et al. 2006. J. Med. Chem. 49, 1475.
Product Information
CAS number881001-19-0
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₇H₁₁ClFN₅O•2.5H₂O
Chemical formulaC₁₇H₁₁ClFN₅O•2.5H₂O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetEGFR/ErbB-2/ErbB-4
Primary Target IC<sub>50</sub>0.3, 1.1, and 0.5 nM for erbB-1, erbB-2, and erbB-4, respectively; 2.5 and 24 nM against EGF- and heregulin-induced erbB autophosphorylation in NIH3T3-erbB-1 and in MDA-MB-453 cells, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
324840 0

Documentation

EGFR/ErbB-2/ErbB-4 Inhibitor - CAS 881001-19-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

EGFR/ErbB-2/ErbB-4 Inhibitor - CAS 881001-19-0 - Calbiochem Certificates of Analysis

TitleLot Number
324840

References

Reference overview
Klutchko, S.R., et al. 2006. J. Med. Chem. 49, 1475.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-May-2010 JSW
SynonymsN-(4-((3-Chloro-4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)2-butynamide
DescriptionA cell-permeable, ATP-binding site-targeting alkynamidopyrimidine compound that acts as a potent and irreversible inhibitor of erbB activities (IC50 = 0.3, 1.1, and 0.5 nM for erbB-1, erbB-2, and erbB-4, respectively). Inhibits EGF- and heregulin-induced erbB autophosphorylation in NIH3T3-erbB-1 and in MDA-MB-453 cells (IC50 = 2.5 and 24 nM, respectively).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number881001-19-0
Chemical formulaC₁₇H₁₁ClFN₅O•2.5H₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (4 mg/ml). Use fresh DMSO only.
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKlutchko, S.R., et al. 2006. J. Med. Chem. 49, 1475.