Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

324841 EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor - CAS 1135256-66-4 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea, PD-089828, PDGFR Tyrosine Kinase Inhibitor XIII

324841
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1135256-66-4C₁₈H₁₈Cl₂N₆O
Description
Overview

This product has been discontinued.



A cell-permeable and reversible protein tyrosine kinase inhibitor that inhibits human FGFR-1, PDGFR-β, c-Src, and EGFR (IC50 = 0.15, 0.18, 1.76, and 5.47 µM, respectively), while exhibiting little activity against InsR, PKC, or CDK4/Cyclin D1 (IC50 >50 µM). The inhibition is shown to be ATP-competitive in the case of FGFR-1, PDGFR-β, and EGFR, but noncompetitive in the case of c-Src.
Catalogue Number324841
Brand Family Calbiochem®
Synonyms1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea, PD-089828, PDGFR Tyrosine Kinase Inhibitor XIII
References
ReferencesHamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.
Dahring, T.K., et al. 1997. J. Pharmacol. Exp. Ther. 281, 1446.
Product Information
CAS number1135256-66-4
FormPale yellow solid
Hill FormulaC₁₈H₁₈Cl₂N₆O
Chemical formulaC₁₈H₁₈Cl₂N₆O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥ 97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-37-45

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable gloves.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
324841 0

Documentation

EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor - CAS 1135256-66-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor - CAS 1135256-66-4 - Calbiochem Certificates of Analysis

TitleLot Number
324841

References

Reference overview
Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.
Dahring, T.K., et al. 1997. J. Pharmacol. Exp. Ther. 281, 1446.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-May-2011 RFH
Synonyms1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea, PD-089828, PDGFR Tyrosine Kinase Inhibitor XIII
DescriptionA cell-permeable and reversible protein tyrosine kinase inhibitor that inhibits human FGFR-1, PDGFR-β, c-Src, and EGFR (IC50 = 0.15, 0.18, 1.76, and 5.47 µM, respectively), while exhibiting little activity against InsR, PKC, or CDK4/Cyclin D1 (IC50 >50 µM). The inhibition is shown to be ATP-competitive in the case of FGFR-1, PDGFR-β, and EGFR, but noncompetitive in the case of c-Src.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1135256-66-4
Chemical formulaC₁₈H₁₈Cl₂N₆O
Structure formulaStructure formula
Purity≥ 97% by HPLC
SolubilityDMSO (25 mg/ml) or Ethanol (1 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesHamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.
Dahring, T.K., et al. 1997. J. Pharmacol. Exp. Ther. 281, 1446.