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317700 Dkk-1 Inhibitor, WAY-262611, HCl - Calbiochem

Dkk-1 Inhibitor, WAY-262611, HCl, CAS 1123231-07-1, counteracts the antagonizing effect of Dkk-1 against Wnt-3a/LRP5 interaction. Prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI

317700
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₀H₂₂N₄ • HCl

Products

Catalogue NumberPackaging Qty/Pack
317700-10MG Glass bottle 10 mg
Description
OverviewA 2-aminopyrimidine compound that counteracts the antagonizing effect of Dkk-1 (Dickkopf-1) against Wnt-3a/LRP5 interaction and prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation and internalization. Shown to successfully rescue cellular response to Wnt-3a stimulation in the presence of Dkk-1 (EC50 = 0.63 µM in a cell-based TCF-luciferase assay) in vitro and double the tibia trabecular bone formation in OVX rats in a period of 28 days via an oral dose of 10 mg/kg/day in vivo.
Catalogue Number317700
Brand Family Calbiochem®
Synonyms(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI
References
ReferencesPelletier, J.C., et al. 2009. J. Med. Chem. 52, 6962.
Product Information
FormYellow powder
FormulationSupplied as a hydrochloride salt.
Hill FormulaC₂₀H₂₂N₄ • HCl
Chemical formulaC₂₀H₂₂N₄ • HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationDkk-1 Inhibitor, WAY-262611, HCl, CAS 1123231-07-1, counteracts the antagonizing effect of Dkk-1 against Wnt-3a/LRP5 interaction. Prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation.
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
317700-10MG 04055977216288

Documentation

Dkk-1 Inhibitor, WAY-262611, HCl - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Dkk-1 Inhibitor, WAY-262611, HCl - Calbiochem Certificates of Analysis

TitleLot Number
317700

References

Reference overview
Pelletier, J.C., et al. 2009. J. Med. Chem. 52, 6962.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-August-2016 JSW
Synonyms(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI
DescriptionA 2-aminopyrimidine compound that counteracts the antagonizing effect of Dkk-1 (Dickkopf-1) against Wnt-3a/LRP5 interaction and prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation and internalization. Shown to successfully rescue cellular response to Wnt-3a stimulation in the presence of Dkk-1 (EC50 = 0.63 µM in a cell-based TCF-luciferase assay) in vitro and double the tibia trabecular bone formation in OVX rats in a period of 28 days via an oral dose of 10 mg/kg/day in vivo.
FormYellow powder
FormulationSupplied as a hydrochloride salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₀H₂₂N₄ • HCl
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesPelletier, J.C., et al. 2009. J. Med. Chem. 52, 6962.