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287840 Diclofenac Sodium - CAS 15307-79-6 - Calbiochem

A cell-permeable, non-selective cyclooxygenase inhibitor (IC₅₀ = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na

Primary Target: COX-1
287840
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
15307-79-6C₁₄H₁₀Cl₂NO₂ · Na

Products

Catalogue NumberPackaging Qty/Pack
287840-1GM 1 gm
Description
OverviewA cell-permeable, non-selective cyclooxygenase inhibitor (IC50 = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity. Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Also inhibits liver phenol sulfotransferase activity (IC50 = 9.5 µM).
Catalogue Number287840
Brand Family Calbiochem®
Synonyms2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na
References
ReferencesKato, M., et al. 2001. J. Pharm. Pharmacol. 53, 1679.
Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81.
Merlos, M., et al. 1996. Inflamm. Res. 45, 20.
Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473.
Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.
Product Information
CAS number15307-79-6
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₄H₁₀Cl₂NO₂ · Na
Chemical formulaC₁₄H₁₀Cl₂NO₂ · Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCOX-1
Primary Target IC<sub>50</sub>60 nM and 200 nM for ovine COX-1 and COX-2 respectively; 9.5 µM against liver phenol sulfotransferase activity
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSAG6330000
Safety Information
R PhraseR: 23/24/25-63

Toxic by inhalation, in contact with skin and if swallowed.
Possible risk of harm to the unborn child.
S PhraseS: 22-36

Do not breathe dust.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
287840-1GM 04055977197877

Documentation

Diclofenac Sodium - CAS 15307-79-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Diclofenac Sodium - CAS 15307-79-6 - Calbiochem Certificates of Analysis

TitleLot Number
287840

References

Reference overview
Kato, M., et al. 2001. J. Pharm. Pharmacol. 53, 1679.
Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81.
Merlos, M., et al. 1996. Inflamm. Res. 45, 20.
Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473.
Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-April-2008 RFH
Synonyms2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na
DescriptionA potent non-steroidal anti-inflammatory drug that inhibits both COX-1 (IC50 = 76 nM) and COX-2 (IC50 = 26 nM) activities. Also inhibits liver phenol sulfotransferase activity (IC50 ~9.5 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation.
FormWhite solid
CAS number15307-79-6
RTECSAG6330000
Chemical formulaC₁₄H₁₀Cl₂NO₂ · Na
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityH₂O (25 mg/ml)
Storage +15°C to +30°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic & Carcinogenic / Teratogenic
Merck USA index14, 3081
ReferencesKato, M., et al. 2001. J. Pharm. Pharmacol. 53, 1679.
Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81.
Merlos, M., et al. 1996. Inflamm. Res. 45, 20.
Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473.
Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.