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HTS013M ChemiSCREEN™ CCR8 Membrane Preparation

Human CCR8 GPCR membrane prepation for Radioligand binding Assays.

Host Cell: Chem-1 Uni Prot Number: P51685 Entrez Gene Number: NM_005201.2
HTS013M
200 assays  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

SpeciesHost CellsProtein Target
Human Chem-1CCR8
Description
Catalogue NumberHTS013M
Brand Family Chemicon®
Trade Name
  • ChemiScreen
  • Chemicon
DescriptionChemiSCREEN™ CCR8 Membrane Preparation
References
Product Information
FormatMembranes
PresentationLiquid in packaging buffer: 50 mM Tris pH 7.4, 10% glycerol and 1% BSA with no preservatives.
Packaging method: Membrane protein was adjusted to 1 mg/ml in packaging buffer, rapidly frozen, and stored at -80°C.
Quality LevelMQ100
Applications
ApplicationHuman CCR8 GPCR membrane prepation for Radioligand binding Assays.
Key Applications
  • Radioligand binding assay
Biological Information
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.
Gene Symbol
  • CCR8
  • CMKBR8
  • MGC129973
  • GPRCY6
  • TER1
  • CKR-L1
  • CCR-8
  • MGC129966
  • CC-CKR-8
  • CY6
  • CKRL1
  • CDw198
  • CMKBRL2
  • GPR-CY6
GPCR ClassA
Host CellsChem-1
Protein TargetCCR8
Target Sub-FamilyChemokine
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P51685 # Receptor for the chemokine SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
SIZE: 355 amino acids; 40844 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: P51685 ## Belongs to the G-protein coupled receptor 1 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size200 assays
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
HTS013M 04053252627194

Documentation

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