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219557 Cerulenin, Cephalosporium caerulens - CAS 17397-89-6 - Calbiochem

An antifungal antibiotic that inhibits sterol and fatty acid biosynthesis.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: sterol & fatty acid biosynthesis
219557
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
17397-89-6C₁₂H₁₇NO₃

Products

Catalogue NumberPackaging Qty/Pack
219557-5MG Plastic ampoule 5 mg
Description
OverviewAn antifungal antibiotic that inhibits sterol and fatty acid biosynthesis. In fatty acid synthesis, reported to bind in equimolar ratio to β-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity. Also shown to inhibit feeding and induce dramatic weight loss in mice.
Catalogue Number219557
Brand Family Calbiochem®
References
ReferencesLoftus, T.M., et al. 2000. Science 288, 2379.
Inokashi, J., et al. 1994. Mol. Gen. Genet. 244, 90.
Schneider, F., et al. 1993. Biochim. Biophys. Acta 1152, 243.
Product Information
CAS number17397-89-6
FormWhite to off-white solid
Hill FormulaC₁₂H₁₇NO₃
Chemical formulaC₁₂H₁₇NO₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetsterol & fatty acid biosynthesis
Purity≥98% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSJR1670000
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
219557-5MG 04055977218138

Documentation

Cerulenin, Cephalosporium caerulens - CAS 17397-89-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cerulenin, Cephalosporium caerulens - CAS 17397-89-6 - Calbiochem Certificates of Analysis

TitleLot Number
219557

References

Reference overview
Loftus, T.M., et al. 2000. Science 288, 2379.
Inokashi, J., et al. 1994. Mol. Gen. Genet. 244, 90.
Schneider, F., et al. 1993. Biochim. Biophys. Acta 1152, 243.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-April-2008 RFH
DescriptionAn anti-fungal antibiotic that inhibits fatty acid biosynthesis by binding, in equimolar ratio, to β-keto-acyl-ACP synthase. Also inhibits sterol synthesis by blocking the activity of HMG-CoA synthetase activity. Systemic and intracerebroventricular of this compound reduces feeding and induces weight loss.
FormWhite to off-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number17397-89-6
RTECSJR1670000
Chemical formulaC₁₂H₁₇NO₃
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (10 mg/ml), Ethanol (5 mg/ml) or Acetone
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
Merck USA index14, 2004
ReferencesLoftus, T.M., et al. 2000. Science 288, 2379.
Inokashi, J., et al. 1994. Mol. Gen. Genet. 244, 90.
Schneider, F., et al. 1993. Biochim. Biophys. Acta 1152, 243.