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219393 Cathepsin S Inhibitor - Calbiochem

Cathepsin S Inhibitor is a slow, tight-binding reversible inhibitor of cathepsin S (Ki = 185 pM). Exhibits 410-fold greater selectivity over cathepsin B (Ki = 76 nM).

Cathepsin S Inhibitor - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-FL-COCHO

Primary Target: cathepsin S
219393
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₄H₂₈N₂O₅
Description
Overview

This product has been discontinued.



A slow, tight-binding reversible inhibitor of recombinant cathepsin S (Ki = 185 pM). Exhibits about 410-fold greater selectivity for cathepsin S compared to cathepsin B (Ki = 76 nM).
Catalogue Number219393
Brand Family Calbiochem®
SynonymsZ-FL-COCHO
References
ReferencesWalker, B., et al. 2000. Biochem. Biophys. Res. Commun. 275, 401.
Product Information
ATP CompetitiveN
Formpale yellow solid
Hill FormulaC₂₄H₂₈N₂O₅
Chemical formulaC₂₄H₂₈N₂O₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCathepsin S Inhibitor is a slow, tight-binding reversible inhibitor of cathepsin S (Ki = 185 pM). Exhibits 410-fold greater selectivity over cathepsin B (Ki = 76 nM).
Biological Information
Primary Targetcathepsin S
Primary Target K<sub>i</sub>185 pM against cathepsin S
Purity≥95% by TLC
Physicochemical Information
Cell permeableN
Peptide SequenceZ-Phe-Leu-COCHO • H₂O
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
219393 0

Documentation

Cathepsin S Inhibitor - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cathepsin S Inhibitor - Calbiochem Certificates of Analysis

TitleLot Number
219393

References

Reference overview
Walker, B., et al. 2000. Biochem. Biophys. Res. Commun. 275, 401.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-November-2009 RFH
SynonymsZ-FL-COCHO
DescriptionA dipeptidyl α-keto-β-aldehyde that acts as a slow, tight-binding, highly potent, reversible inhibitor of cathepsin S. Exhibits over 410-fold greater selectivity for cathepsin S (Ki = 185 pM) over cathepsin B (Ki = 76 nM).
Formpale yellow solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₄H₂₈N₂O₅
Peptide SequenceZ-Phe-Leu-COCHO • H₂O
Structure formulaStructure formula
Purity≥95% by TLC
SolubilityDMSO (5 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesWalker, B., et al. 2000. Biochem. Biophys. Res. Commun. 275, 401.