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218772 Caspase Inhibitor Set II - Calbiochem

Caspase Inhibitor Set II - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: caspase-1, caspase-2, caspase-4, caspase-5, caspase-6, caspase-7, caspase-8, caspase-9
218772
  
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Overview

Replacement Information
Description
Overview

This product has been discontinued.



A set of eight cell-permeable, irreversible inhibitors of various caspase-family proteases. Contains 250 µg each of Caspase-1 Inhibitor VI, Z-YVAD-FMK (Cat. No. 218746); Caspase-2 Inhibitor I, Z-VDVAD-FMK (Cat. No. 218744); Caspase-3 Inhibitor II, Z-DEVD-FMK (Cat. No. 264155); Caspase-5 Inhibitor I, Z-WEHD-FMK (Cat. No. 218753); Caspase-6 Inhibitor I, Z-VEID-FMK (Cat. No. 218757); Caspase-8 Inhibitor II, Z-IETD-FMK (Cat. No. 218759); Caspase-9 Inhibitor I, Z-LEHD-FMK (Cat. No. 218761); and Caspase Inhibitor III, Boc-D-FMK (Cat. No. 218745). Supplied with a data sheet.
Catalogue Number218772
Brand Family Calbiochem®
References
ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Humke, E.W., et al. 1998. J. Biol. Chem. 273, 15702.
Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
Nicholson, D.W., et al. 1995. Nature 376, 37.
Thornberry, N.A., et al. 1992. Nature 356, 768.
Product Information
FormSolid
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary Targetcaspase-1, caspase-2, caspase-4, caspase-5, caspase-6, caspase-7, caspase-8, caspase-9
Secondary targetgranzyme B
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFrom Catalog:
Desc. Field- added "A set of eight cell-permeable, irreversible inhibitors of various caspase-family proteases
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
218772 0

Documentation

Caspase Inhibitor Set II - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caspase Inhibitor Set II - Calbiochem Certificates of Analysis

TitleLot Number
218772

References

Reference overview
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Humke, E.W., et al. 1998. J. Biol. Chem. 273, 15702.
Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
Nicholson, D.W., et al. 1995. Nature 376, 37.
Thornberry, N.A., et al. 1992. Nature 356, 768.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-June-2008 RFH
DescriptionApoptosis is a normal process in development and morphogenesis. Many cells can be activated to undergo apoptosis following the interaction of selected ligands with cell surface receptors. Receptor-mediated apoptosis involves the activation of caspases (cysteine-containing aspartate-specific proteases). A distinctive feature of caspases is the requirement of an aspartic acid residue in the substrate P1 position.

Caspase inhibitors act by binding to the active site of caspases and form either a reversible or an irreversible linkage. Caspase inhibitor design includes a peptide recognition sequence attached to a functional group such as an aldehyde (CHO), chloromethylketone (CMK), fluoromethylketone (FMK), or fluoroacyloxymethylketone (FAOM). Caspase inhibitors with a CHO group are reversible and those with a CMK, FMK, or FAOM group are irreversible. FMK exhibits slightly less reactivity than CMK and therefore is more specific for the enzyme being inhibited.
FormSolid
Storage Protect from moisture
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFrom Catalog:
Desc. Field- added "A set of eight cell-permeable, irreversible inhibitors of various caspase-family proteases
Toxicity Standard Handling
ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Humke, E.W., et al. 1998. J. Biol. Chem. 273, 15702.
Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
Nicholson, D.W., et al. 1995. Nature 376, 37.
Thornberry, N.A., et al. 1992. Nature 356, 768.