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400012 Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem

Caspase-1 Inhibitor II, CAS 178603-78-6, is a cell-permeable, irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: IL-1β Converting Enzyme (ICE) Inhibitor II, Ac-YVAD-CMK

Primary Target: caspase-1
400012
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
178603-78-6C₂₄H₃₃ClN₄O₈

Products

Catalogue NumberPackaging Qty/Pack
400012-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable and irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.
Catalogue Number400012
Brand Family Calbiochem®
SynonymsIL-1β Converting Enzyme (ICE) Inhibitor II, Ac-YVAD-CMK
References
ReferencesBrenner, B., et al. 1998. Cell Death Differ. 5, 29.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Enari, M., et al. 1995. Nature 375, 78.
Walker, N.P.C., et al. 1994. Cell 78, 343.
Thornberry, N., et al. 1992. Nature 356, 768.
Product Information
CAS number178603-78-6
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₄H₃₃ClN₄O₈
Chemical formulaC₂₄H₃₃ClN₄O₈
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCaspase-1 Inhibitor II, CAS 178603-78-6, is a cell-permeable, irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5.
Biological Information
Primary Targetcaspase-1
Primary Target K<sub>i</sub>760 pM against caspase-1
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceAc-Tyr-Val-Ala-Asp-CMK
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
400012-5MG 07790788049928

Documentation

Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem Certificates of Analysis

TitleLot Number
400012

References

Reference overview
Brenner, B., et al. 1998. Cell Death Differ. 5, 29.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Enari, M., et al. 1995. Nature 375, 78.
Walker, N.P.C., et al. 1994. Cell 78, 343.
Thornberry, N., et al. 1992. Nature 356, 768.

Citations

Title
  • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision22-November-2010 JSW
    SynonymsIL-1β Converting Enzyme (ICE) Inhibitor II, Ac-YVAD-CMK
    DescriptionInterleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.
    FormWhite solid
    CAS number178603-78-6
    Chemical formulaC₂₄H₃₃ClN₄O₈
    Peptide SequenceAc-Tyr-Val-Ala-Asp-CMK
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityDMSO (5 mg/ml)
    Storage Protect from moisture
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesBrenner, B., et al. 1998. Cell Death Differ. 5, 29.
    Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
    Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
    Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
    Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
    Enari, M., et al. 1995. Nature 375, 78.
    Walker, N.P.C., et al. 1994. Cell 78, 343.
    Thornberry, N., et al. 1992. Nature 356, 768.
    Citation
  • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
    		•