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208722 Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem

208722
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Overview

Key Spec Table

CAS #Empirical Formula
88191-84-8C₂₂H₂₆N₂O₄

Products

Catalogue NumberPackaging Qty/Pack
208722-25MG Plastic ampoule 25 mg
Description
OverviewA potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM). Reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effect in glutamate-induced toxicity.
Catalogue Number208722
Brand Family Calbiochem®
SynonymsCarbobenzoxy-valinyl-phenylalaninal, MDL 28170
References
ReferencesChatterjee, S., et al. 1998. J. Med. Chem. 41, 2663.
Rami, A., et al. 1997. Neurosci. Res. 27, 93.
Yamazaki, T., et al. 1997. Biochemistry 36, 8377.
Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
Chard, P.S., et al. 1995. Neuroscience 65, 1099.
Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.
Product Information
CAS number88191-84-8
ATP CompetitiveN
FormWhite lyophilized solid
Hill FormulaC₂₂H₂₆N₂O₄
Chemical formulaC₂₂H₂₆N₂O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCalpain Inhibitor III, CAS 88191-84-8, is a potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM).
Biological Information
Primary Targetcalpain 1, calpain 2
Primary Target IC<sub>50</sub>8 nM
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Val-Phe-CHO
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Global Trade Item Number
Catalogue Number GTIN
208722-25MG 04055977202687