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208722 Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem

Calpain Inhibitor III, CAS 88191-84-8, is a potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Carbobenzoxy-valinyl-phenylalaninal, MDL 28170

Primary Target: calpain 1, calpain 2
208722
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
88191-84-8C₂₂H₂₆N₂O₄

Products

Catalogue NumberPackaging Qty/Pack
208722-25MG Plastic ampoule 25 mg
Description
OverviewA potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM). Reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effect in glutamate-induced toxicity.
Catalogue Number208722
Brand Family Calbiochem®
SynonymsCarbobenzoxy-valinyl-phenylalaninal, MDL 28170
References
ReferencesChatterjee, S., et al. 1998. J. Med. Chem. 41, 2663.
Rami, A., et al. 1997. Neurosci. Res. 27, 93.
Yamazaki, T., et al. 1997. Biochemistry 36, 8377.
Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
Chard, P.S., et al. 1995. Neuroscience 65, 1099.
Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.
Product Information
CAS number88191-84-8
ATP CompetitiveN
FormWhite lyophilized solid
Hill FormulaC₂₂H₂₆N₂O₄
Chemical formulaC₂₂H₂₆N₂O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCalpain Inhibitor III, CAS 88191-84-8, is a potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM).
Biological Information
Primary Targetcalpain 1, calpain 2
Primary Target IC<sub>50</sub>8 nM
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Val-Phe-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
208722-25MG 04055977202687

Documentation

Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem Certificates of Analysis

TitleLot Number
208722

References

Reference overview
Chatterjee, S., et al. 1998. J. Med. Chem. 41, 2663.
Rami, A., et al. 1997. Neurosci. Res. 27, 93.
Yamazaki, T., et al. 1997. Biochemistry 36, 8377.
Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
Chard, P.S., et al. 1995. Neuroscience 65, 1099.
Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.

Citations

Title
  • Dong, Y., et al. 2009. J. Cell Mol. Med. 13, 2899.
  • Dong, Y., et al. 2006. FASEB Journal in press,.
  • So-Young Park and Adriana Ferreira. 2005. Journal of Neuroscience 25, 5365.
  • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision28-May-2008 RFH
    SynonymsCarbobenzoxy-valinyl-phenylalaninal, MDL 28170
    DescriptionA potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity.
    FormWhite lyophilized solid
    CAS number88191-84-8
    Chemical formulaC₂₂H₂₆N₂O₄
    Peptide SequenceZ-Val-Phe-CHO
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityDMSO (20 mg/ml). Use only anhydrous DMSO.
    Storage +2°C to +8°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    Toxicity Standard Handling
    ReferencesChatterjee, S., et al. 1998. J. Med. Chem. 41, 2663.
    Rami, A., et al. 1997. Neurosci. Res. 27, 93.
    Yamazaki, T., et al. 1997. Biochemistry 36, 8377.
    Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
    Chard, P.S., et al. 1995. Neuroscience 65, 1099.
    Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.
    Citation
  • Dong, Y., et al. 2009. J. Cell Mol. Med. 13, 2899.
  • Dong, Y., et al. 2006. FASEB Journal in press,.
  • So-Young Park and Adriana Ferreira. 2005. Journal of Neuroscience 25, 5365.
  • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
    		•