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239824 CXCR7 Agonist, VUF11207 - CAS 1378524-41-4 - Calbiochem

CXCR7 Agonist, VUF11207, CAS 1378524-41-4, is a high affinity and high potency ligand of CXCR7 (pKi = 8.1). Induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E)-N-(3-(2-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide, RDC1 agonist, CMKOR1 Agonist, CXCR-7 Agonist, CXC-R7 Agonist, RDC-1 Agonist, GPR159 Agonist

Primary Target: CXCR7
239824
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1378524-41-4C₂₇H₃₅FN₂O₄

Products

Catalogue NumberPackaging Qty/Pack
239824-10MG Glass bottle 10 mg
Description
OverviewA styrene-amide derivative that acts as a high affinity and high potency ligand of CXCR7 chemokine receptor (pKi = 8.1) and induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7. Exposure of HEK293 T cells transiently transfected with cDNA encoding both CXCR7-RLuc and β-arrestin 2-YFP to VUF11207 is shown to induce a dose-dependent increase in bioluminescence resonance energy transfer (BRET) signal (EC50 = 1.6 nM) indicating its agonist role in β-arrestin2 is recruited to the active receptor.
Catalogue Number239824
Brand Family Calbiochem®
Synonyms(E)-N-(3-(2-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide, RDC1 agonist, CMKOR1 Agonist, CXCR-7 Agonist, CXC-R7 Agonist, RDC-1 Agonist, GPR159 Agonist
References
ReferencesWijtmans, M., et al. 2011, Eur J Med Chem 51, 184.
Product Information
CAS number1378524-41-4
FormLight yellow oil
Hill FormulaC₂₇H₃₅FN₂O₄
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCXCR7 Agonist, VUF11207, CAS 1378524-41-4, is a high affinity and high potency ligand of CXCR7 (pKi = 8.1). Induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7.
Biological Information
Primary TargetCXCR7
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
239824-10MG 04055977198980

Documentation

CXCR7 Agonist, VUF11207 - CAS 1378524-41-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

CXCR7 Agonist, VUF11207 - CAS 1378524-41-4 - Calbiochem Certificates of Analysis

TitleLot Number
239824

References

Reference overview
Wijtmans, M., et al. 2011, Eur J Med Chem 51, 184.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-June-2020 JSW
Synonyms(E)-N-(3-(2-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide, RDC1 agonist, CMKOR1 Agonist, CXCR-7 Agonist, CXC-R7 Agonist, RDC-1 Agonist, GPR159 Agonist
DescriptionA styrene-amide derivative that acts as a high affinity and high potency ligand of CXCR7 chemokine receptor (pKi = 8.1) and induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7. Exposure of HEK293 T cells transiently transfected with cDNA encoding both CXCR7-RLuc and β-arrestin 2-YFP to VUF11207 is shown to induce a dose-dependent increase in bioluminescence resonance energy transfer (BRET) signal (EC50 = 1.6 nM) indicating its agonist role in β-arrestin2 is recruited to the active receptor.
FormLight yellow oil
Intert gas (Yes/No) Packaged under inert gas
CAS number1378524-41-4
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWijtmans, M., et al. 2011, Eur J Med Chem 51, 184.