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239824 CXCR7 Agonist, VUF11207 - CAS 1378524-41-4 - Calbiochem

CXCR7 Agonist, VUF11207, CAS 1378524-41-4, is a high affinity and high potency ligand of CXCR7 (pKi = 8.1). Induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: RDC-1 Agonist, GPR159 Agonist, (E)-N-(3-(2-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide, RDC1 agonist, CMKOR1 Agonist, CXCR-7 Agonist, CXC-R7 Agonist

Primary Target: CXCR7
239824
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Overview

Key Spec Table

CAS #Empirical Formula
1378524-41-4C₂₇H₃₅FN₂O₄

Products

Catalogue NumberPackaging Qty/Pack
239824-10MG Glass bottle 10 mg
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Description
OverviewA styrene-amide derivative that acts as a high affinity and high potency ligand of CXCR7 chemokine receptor (pKi = 8.1) and induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7. Exposure of HEK293 T cells transiently transfected with cDNA encoding both CXCR7-RLuc and β-arrestin 2-YFP to VUF11207 is shown to induce a dose-dependent increase in bioluminescence resonance energy transfer (BRET) signal (EC50 = 1.6 nM) indicating its agonist role in β-arrestin2 is recruited to the active receptor.
Catalogue Number239824
Brand Family Calbiochem®
SynonymsRDC-1 Agonist, GPR159 Agonist, (E)-N-(3-(2-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide, RDC1 agonist, CMKOR1 Agonist, CXCR-7 Agonist, CXC-R7 Agonist
References
ReferencesWijtmans, M., et al. 2011, Eur J Med Chem 51, 184.
Product Information
CAS number1378524-41-4
FormLight yellow oil
Hill FormulaC₂₇H₃₅FN₂O₄
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCXCR7 Agonist, VUF11207, CAS 1378524-41-4, is a high affinity and high potency ligand of CXCR7 (pKi = 8.1). Induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7.
Biological Information
Primary TargetCXCR7
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
239824-10MG 04055977198980