Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

220201 CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem

CAS 75621-03-3 is a zwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate

220201
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
75621-03-3C₃₂H₅₈N₂O₇S

Products

Catalogue NumberPackaging Qty/Pack
220201-10GM Plastic bottle 10 gm
220201-1GM Plastic bottle 1 gm
220201-1KG Plastic bottle 1 kg
220201-250GM Plastic bottle 250 gm
220201-25GM Plastic bottle 25 gm
220201-5GM Plastic bottle 5 gm
Description
OverviewZwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines. Better at solubilizing proteins than structurally-related carboxylic acid anions and is much more effective at breaking protein-protein interactions than either sodium cholate or TRITON® X-100 Detergent. Capable of solubilizing the opiate receptor to a state exhibiting reversible binding of opiates. Also, capable of disaggregating cytochrome P450 to its monomeric form without denaturation. Has a small micellar molecular weight and a high critical micellar concentration and can be removed from either gels or protein solutions by dialysis across a membrane. Aggregation number: 4-14.
Conductivity (1.0 M, 24°C): <100 µmhos.
Catalogue Number220201
Brand Family Calbiochem®
Synonyms3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
References
ReferencesChen, Y., et al. 1992. Biochemistry 31, 2415.
Ofri, D., et al. 1992. J. Neurochem. 58, 628.
Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.
Product Information
CAS number75621-03-3
Aggregation Number4 - 14
CMC6 - 10 mM
FormWhite crystalline powder
Hill FormulaC₃₂H₅₈N₂O₇S
Chemical formulaC₃₂H₅₈N₂O₇S
Hygroscopic Hygroscopic
Micellar weight6150
Quality LevelMQ300
Applications
Biological Information
Purity≥98% by NMR
Physicochemical Information
ContaminantsDNase, RNase, and Protease: none detected
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22-36/38

Harmful if swallowed.
Irritating to eyes and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +15°C to +30°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
220201-10GM 07790788048754
220201-1GM 04055977200973
220201-1KG 04055977200980
220201-250GM 04055977201017
220201-25GM 04055977201000
220201-5GM 04055977201024

Documentation

CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem Certificates of Analysis

TitleLot Number
220201

References

Reference overview
Chen, Y., et al. 1992. Biochemistry 31, 2415.
Ofri, D., et al. 1992. J. Neurochem. 58, 628.
Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.

Brochure

Title
CALBIOSORBﾙ Technical Bulletin
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-November-2010 RFH
Synonyms3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
DescriptionNon-denaturing zwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines. Better at solubilizing proteins than the structurally related carboxylic acid anions, and is more effective at breaking protein-protein interactions than either sodium cholate or TRITON® X-100. Capable of solubilizing the opiate receptor to a state exhibiting reversible binding to opiates. Also capable of disaggregating P 450 to its monomeric form without denaturation. Has a small micellar molecular weight (6150 Daltons) and a high critical micellar concentration (6-10 mM). Can be removed from either gels or protein solutions by dialysis. Aggregation number: 4-14.
FormWhite crystalline powder
CAS number75621-03-3
Chemical formulaC₃₂H₅₈N₂O₇S
Purity≥98% by NMR
ContaminantsDNase, RNase, and Protease: none detected
SolubilityH₂O (1.0 M)
Storage +15°C to +30°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Toxicity Harmful
Merck USA index14, 2044
ReferencesChen, Y., et al. 1992. Biochemistry 31, 2415.
Ofri, D., et al. 1992. J. Neurochem. 58, 628.
Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.