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14-499M Bmx Protein, active, 250 µg

Active, N-terminal His6 tagged, recombinant, full length, human Bmx, for use in Kinase Assays.

Bmx Protein, active, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
14-499M
250 µg  Also available in 10 μg size (cat#14-499) and in bulk (cat# 14-499-K).
Purchase on Sigma-Aldrich

Overview

Description
Catalogue Number14-499M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionBmx Protein, active, 250 µg
OverviewN-terminal His6 tagged, recombinant, full length, human Bmx
Product Information
Quality LevelMQ100
Applications
ApplicationActive, N-terminal His6 tagged, recombinant, full length, human Bmx, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Sourceexpressed in Sf21 cells
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryTyrosine kinases are either receptor molecules, which contain transmembrane and extracellular domains, or nonreceptor proteins, which are located intracellularly. One family of nonreceptor TKs includes the genes TEC (MIM 600583), TXK (MIM 600058), ITK (MIM 186973), and BTK (MIM 300300). All of these proteins are homologs of the Drosophila Src28 TK and contain an SH3 and SH2 domain upstream of the TK domain.[supplied by OMIM]
Gene Symbol
  • BMX
  • PSCTK2
  • PSCTK3
  • NTK38
  • ETK
Protein TargetBmx
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyTK
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P51813 # Activity is required for interleukin 6 (IL-6) induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells.
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
SIZE: 675 amino acids; 78011 Da
SUBUNIT: Interacts with RUFY1 and RUFY2.
SUBCELLULAR LOCATION: Cytoplasm (Probable).
TISSUE SPECIFICITY: Preferentially expressed in epithelial and endothelial cells.
DOMAIN: SwissProt: P51813 SH2 domain mediates interaction with RUFY1.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. & Contains 1 Btk-type zinc finger. & Contains 1 PH domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain.
Molecular Weight79kDa
Product Usage Statements
Quality Assuranceroutinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-499) and in bulk (cat# 14-499-K).
Global Trade Item Number
Catalogue Number GTIN
14-499M 04053252406614