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203401 Bleomycin Sulfate, Streptomyces verticillus - CAS 9041-93-4 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
203401
  
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Overview

Replacement Information

Key Spec Table

CAS #
9041-93-4
Description
Overview

This product has been discontinued.



Mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An anti-neoplastic agent. Bleomycin has been used in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas.
Catalogue Number203401
Brand Family Calbiochem®
References
ReferencesTounekki, O., et al. 1994. Bull. Cancer 81, 1043.
Chauvergne, J., et al. 1993. Bull. Cancer 80, 70.
Ikeda, S., et al. 1991. Anal. Biochem. 192, 96.
Hait, W.N., et al. 1990. Cancer Res. 50, 6636.
Arkin, H., et al. 1989. Cancer Res. 49, 6556.
Wu, J.C., et al. 1983. J. Biol. Chem. 258, 4694.
Takita, T., et al. 1968. Antibiotics 21, 79.
Product Information
CAS number9041-93-4
FormWhite to off-white solid
Hygroscopic Hygroscopic
Quality LevelMQ100
Applications
Biological Information
Biological activityPotency: 1.5-2.0 U/mg
Purity≥90% by HPLC (A₂ + B₂)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSEC5991990
Safety Information
R PhraseR: 20/21/22-36/37/38-40-42/43

Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
Limited evidence of a carcinogenic effect.
May cause sensitization by inhalation and skin contact.
S PhraseS: 22-26-36/37/39-45

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions (≥3 units/ml) are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
203401 0

Documentation

Bleomycin Sulfate, Streptomyces verticillus - CAS 9041-93-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Bleomycin Sulfate, Streptomyces verticillus - CAS 9041-93-4 - Calbiochem Certificates of Analysis

TitleLot Number
203401

References

Reference overview
Tounekki, O., et al. 1994. Bull. Cancer 81, 1043.
Chauvergne, J., et al. 1993. Bull. Cancer 80, 70.
Ikeda, S., et al. 1991. Anal. Biochem. 192, 96.
Hait, W.N., et al. 1990. Cancer Res. 50, 6636.
Arkin, H., et al. 1989. Cancer Res. 49, 6556.
Wu, J.C., et al. 1983. J. Biol. Chem. 258, 4694.
Takita, T., et al. 1968. Antibiotics 21, 79.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-August-2007 JSW
DescriptionA mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An antineoplastic agent capable of mimicking apoptosis. Useful in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas.
FormWhite to off-white solid
CAS number9041-93-4
RTECSEC5991990
Purity≥90% by HPLC (A₂ + B₂)
Biological activityPotency: 1.5-2.0 U/mg
SolubilityH₂O (20 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions (≥3 units/ml) are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
Merck USA index14, 1318
ReferencesTounekki, O., et al. 1994. Bull. Cancer 81, 1043.
Chauvergne, J., et al. 1993. Bull. Cancer 80, 70.
Ikeda, S., et al. 1991. Anal. Biochem. 192, 96.
Hait, W.N., et al. 1990. Cancer Res. 50, 6636.
Arkin, H., et al. 1989. Cancer Res. 49, 6556.
Wu, J.C., et al. 1983. J. Biol. Chem. 258, 4694.
Takita, T., et al. 1968. Antibiotics 21, 79.