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203325 BMS - CAS 145626-87-5 - Calbiochem

Water-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT.

BMS - CAS 145626-87-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: bis(2-Mercaptoethylsulfone)

203325
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
145626-87-5C₄H₁₀O₂S₃
Description
OverviewWater-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT. Shown to reduce accessible disulfide bonds in immunoglobulin and trypsinogen under non-denaturing conditions 5 to 7 times faster than DTT at pH 7. The relatively less accessible disulfide bond in α-chymotrypsinogen A was reduced 2.3 times faster at with BMS than with DTT at pH 7.0.
Catalogue Number203325
Brand Family Calbiochem®
Synonymsbis(2-Mercaptoethylsulfone)
References
ReferencesSingh, R., et al. 1995. Methods Enzymol. 251, 167.
Singh, R., and Whitesides, G.M. 1994. Bioorg. Chem. 22, 109.
Singh, R., and Whitesides, G.M. 1994. Protein Sci. 3, Suppl. 1, 430T.
Lamoureux, G.V., and Whitesides, G.M. 1993. J. Org. Chem. 58, 633.
Product Information
CAS number145626-87-5
FormWhite crystalline solid
Hill FormulaC₄H₁₀O₂S₃
Chemical formulaC₄H₁₀O₂S₃
PKA7.9 and 9.0
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by titration
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
203325 0

Documentation

BMS - CAS 145626-87-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

BMS - CAS 145626-87-5 - Calbiochem Certificates of Analysis

TitleLot Number
203325

References

Reference overview
Singh, R., et al. 1995. Methods Enzymol. 251, 167.
Singh, R., and Whitesides, G.M. 1994. Bioorg. Chem. 22, 109.
Singh, R., and Whitesides, G.M. 1994. Protein Sci. 3, Suppl. 1, 430T.
Lamoureux, G.V., and Whitesides, G.M. 1993. J. Org. Chem. 58, 633.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
Synonymsbis(2-Mercaptoethylsulfone)
DescriptionWater-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT. Shown to reduce accessible disulfide bonds in immunoglobulin and trypsinogen under non-denaturing conditions 5 to 7 times faster than DTT at pH 7. The relatively less accessible disulfide bond in α-chymotrypsinogen A was reduced 2.3 times faster at pH 7 with BMS than with DTT. Has a pKa of 7.9 and 9.0.
FormWhite crystalline solid
Intert gas (Yes/No) Packaged under inert gas
CAS number145626-87-5
Chemical formulaC₄H₁₀O₂S₃
Structure formulaStructure formula
Purity≥99% by titration
SolubilityDMSO, Ethanol, H₂O (1.8 mg/ml), or Methanol. May require warming (40-45°C) to achieve complete solubilization in H₂O.
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesSingh, R., et al. 1995. Methods Enzymol. 251, 167.
Singh, R., and Whitesides, G.M. 1994. Bioorg. Chem. 22, 109.
Singh, R., and Whitesides, G.M. 1994. Protein Sci. 3, Suppl. 1, 430T.
Lamoureux, G.V., and Whitesides, G.M. 1993. J. Org. Chem. 58, 633.