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505980 Autophagy Inhibitor IV, Cpd18 - Calbiochem

505980
Purchase on Sigma-Aldrich

Overview

Key Spec Table

Empirical Formula
C₁₂H₁₇N₅

Products

Catalogue NumberPackaging Qty/Pack
5.05980.0001 Glass bottle 10 mg
Description
OverviewA cell-permeable 3-methyladenine (3-MA) derivative that acts as an autophagy inhibitor via the inhibition of class III PI3K, and without touching class I PI3K. Shown to block 80% of starvation-induced autophagy at 1 mM (IC50 = 0.67 mM, compared with 3-MA at 6 mM). Displays much better solubility than 3-MA (5 times more soluble in water and 30 times more soluble in DMSO). Also found to reduce cell viability by 55% at 1 mM at 12 hours compared with 72% reduction for 3-MA at 10 mM.

Please note that the molecular weight for this compound is lot-specific due to variable water content.
Catalogue Number505980
Brand Family Calbiochem®
Synonyms3-methyl-6-(3-methylpiperidin-1-yl)-3H-purine, 3-MA analog, Cpd 18
References
ReferencesWu, Y., et al, 2013. Autophagy9, 595.
Product Information
FormWhite solid
Hill FormulaC₁₂H₁₇N₅
Chemical formulaC₁₂H₁₇N₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetPI3K
Primary Target IC<sub>50</sub>0.67 mM
Purity≥98% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
5.05980.0001 04055977262520