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505980 Autophagy Inhibitor IV, Cpd18 - Calbiochem

Autophagy Inhibitor IV, Cpd18 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-methyl-6-(3-methylpiperidin-1-yl)-3H-purine, 3-MA analog, Cpd 18

Primary Target: PI3K
505980
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₂H₁₇N₅

Products

Catalogue NumberPackaging Qty/Pack
5.05980.0001 Glass bottle 10 mg
Description
OverviewA cell-permeable 3-methyladenine (3-MA) derivative that acts as an autophagy inhibitor via the inhibition of class III PI3K, and without touching class I PI3K. Shown to block 80% of starvation-induced autophagy at 1 mM (IC50 = 0.67 mM, compared with 3-MA at 6 mM). Displays much better solubility than 3-MA (5 times more soluble in water and 30 times more soluble in DMSO). Also found to reduce cell viability by 55% at 1 mM at 12 hours compared with 72% reduction for 3-MA at 10 mM.

Please note that the molecular weight for this compound is lot-specific due to variable water content.
Catalogue Number505980
Brand Family Calbiochem®
Synonyms3-methyl-6-(3-methylpiperidin-1-yl)-3H-purine, 3-MA analog, Cpd 18
References
ReferencesWu, Y., et al, 2013. Autophagy9, 595.
Product Information
FormWhite solid
Hill FormulaC₁₂H₁₇N₅
Chemical formulaC₁₂H₁₇N₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPI3K
Primary Target IC<sub>50</sub>0.67 mM
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.05980.0001 04055977262520

Documentation

Autophagy Inhibitor IV, Cpd18 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Autophagy Inhibitor IV, Cpd18 - Calbiochem Certificates of Analysis

TitleLot Number
505980

References

Reference overview
Wu, Y., et al, 2013. Autophagy9, 595.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-October-2013 JSW
Synonyms3-methyl-6-(3-methylpiperidin-1-yl)-3H-purine, 3-MA analog, Cpd 18
DescriptionA cell-permeable 3-methyladenine (3-MA) derivative that acts as an autophagy inhibitor via the inhibition of class III PI3K, and without touching class I PI3K. Shown to block 80% of starvation - induced autophagy at 1 mM (IC50 = 0.67 mM, compared with 3-MA at 6 mM). Displays much better solubility than 3-MA (5 times more soluble in water and 30 times more soluble in DMSO). Also found to reduce cell viability by 55% at 1 mM at 12 hours compared with 72% reduction for 3-MA at 10 mM.
FormWhite solid
Chemical formulaC₁₂H₁₇N₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWu, Y., et al, 2013. Autophagy9, 595.