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178486 Apoptosis Inducer Set I - Calbiochem

This set contains five ready-to-use chemical reagents that induce apoptosis through different mechanisms.

Apoptosis Inducer Set I - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
178486
  
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Overview

Replacement Information
Description
OverviewThis set contains five ready-to-use chemical reagents that induce apoptosis through different mechanisms. The set contains DMSO solutions of Actinomycin D, Streptomyces sp. (10 mM; Cat. No. 114666), Camptothecin, Camptotheca acuminata (2 mM; Cat. No. 208925), Cycloheximide (100 mM; Cat. No. 239764), Dexamethasone (10 mM; Cat. No. 265005), and Etoposide (100 mM; Cat. No. 341205). Recommended dilution for use: 1:1000. Supplied with a data sheet.
Catalogue Number178486
Brand Family Calbiochem®
Application Data
References
ReferencesSuzuki, A., and Keto, M. 1996. Exp. Cell. Res. 227, 154.
Martin, S.J., et al. 1995. J. Exp. Med. 182, 1545.
Nicholson, D.W., et al. 1995. Nature 376, 37.
Fearnhead, H.O., et al. 1994. Biochem. Pharmacol. 48, 1073.
Onishi, Y., et al. 1993. Biochem. Biophys. Acta 1175, 147.
Product Information
FormLiquid
FormulationAll components are supplied in DMSO.
Quality LevelMQ100
Applications
Biological Information
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 26/27/28-36/37/38-43-45-46-40-61-62-63

Very toxic by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
May cause sensitization by skin contact.
May cause cancer.
May cause heritable genetic damage.
Limited evidence of a carcinogenic effect.
May cause harm to the unborn child.
Possible risk of impaired fertility.
Possible risk of harm to the unborn child.
S PhraseS: 26-36/37/39-45-53-3/7/9-23

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid exposure - obtain special instructions before use.
Keep container tightly closed, in a cool well ventilated place.
Do not breathe fumes.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Multiple Toxicity Values, refer to MSDS
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
178486 0

Documentation

Apoptosis Inducer Set I - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Apoptosis Inducer Set I - Calbiochem Certificates of Analysis

TitleLot Number
178486

References

Reference overview
Suzuki, A., and Keto, M. 1996. Exp. Cell. Res. 227, 154.
Martin, S.J., et al. 1995. J. Exp. Med. 182, 1545.
Nicholson, D.W., et al. 1995. Nature 376, 37.
Fearnhead, H.O., et al. 1994. Biochem. Pharmacol. 48, 1073.
Onishi, Y., et al. 1993. Biochem. Biophys. Acta 1175, 147.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-April-2008 RFH
Application Data
DescriptionThe set contains 5 ready-to-use chemical reagents that induce apoptosis through different mechanisms. Actinomycin D, an anti-neoplastic antibiotic, inhibits RNA synthesis. Camptothecin and etoposide are inhibitors of nuclear topoisomerase. Cycloheximide, an active antibiotic against many yeast and fungi, inhibits protein synthesis. Dexamethasone, an active and highly stable glucocorticoid, probably induces apoptosis by binding and activating the intracellular glucocorticoid receptor. Supplied with a data sheet.
FormLiquid
FormulationAll components are supplied in DMSO.
Recommended reaction conditionsA 1:1000 is recommended for inducing apoptosis in cell culture with these apoptosis-inducing reagents. The optimal dosie may vary for different cell types and culture conditions. Please consult published literature to determine the optimal concentration and incubation time for specific cell types.
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Multiple Toxicity Values, refer to MSDS
ReferencesSuzuki, A., and Keto, M. 1996. Exp. Cell. Res. 227, 154.
Martin, S.J., et al. 1995. J. Exp. Med. 182, 1545.
Nicholson, D.W., et al. 1995. Nature 376, 37.
Fearnhead, H.O., et al. 1994. Biochem. Pharmacol. 48, 1073.
Onishi, Y., et al. 1993. Biochem. Biophys. Acta 1175, 147.