178273 Sigma-AldrichAphidicolin - CAS 38966-21-1 - Calbiochem
Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase.
More>> Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. Less<<Aphidicolin - CAS 38966-21-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 38966-21-1 | C₂₀H₃₄O₄ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 178273-1MG | Plastic ampoule | 1 mg |
| Description | |
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| Overview | A cell-permeable tetracyclic diterpene antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLa S3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3. Also available as a 30 mM solution in DMSO (Cat. No. 504744). |
| Catalogue Number | 178273 |
| Brand Family | Calbiochem® |
| Product Information | |
|---|---|
| CAS number | 38966-21-1 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₂₀H₃₄O₄ |
| Chemical formula | C₂₀H₃₄O₄ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | DNA polymerase α, DNA polymerase δ |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS | |
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| RTECS | PB9185000 |
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| Product Usage Statements |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 178273-1MG | 04055977223163 |
Documentation
Aphidicolin - CAS 38966-21-1 - Calbiochem SDS
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Aphidicolin - CAS 38966-21-1 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 178273 |
References
| Reference overview |
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| Borner, M.M., et al. 1995. Cancer Res. 55, 2122. Poluha, W., et al. 1995. Oncogene 10, 185. Urbani, L., et al. 1995. Exp. Cell Res. 219, 159. Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311. Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909. Hubermann, J.A. 1981. Cell 23, 647. |