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ABS2119 Anti-TTC39B

Anti-TTC39B, Cat. No. ABS2119, is a rabbit polyclonal antibody that detects Tetratricopeptide repeat protein 39B and has been tested for use in Western Blotting.

Anti-TTC39B MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Gene Symbol: TTC39B, C9orf52 UniProt Number: Q5VTQ0
ABS2119
100 μg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
M, HWBRbPurifiedPolyclonal Antibody
Description
Catalogue NumberABS2119
DescriptionAnti-TTC39B
Alternate Names
  • Tetratricopeptide repeat protein 39B
  • TPR repeat protein 39B
Background InformationTetratricopeptide repeat protein 39B (UniProt: also known as TPR repeat protein 39B, TTC39B) is encoded by the TTC39B (also known as C9orf52) gene (Gene ID: 158219) in human. TTC39B protein contains two TPR repeats (aa 393-426 and 626-659). TCC39B protein is the product of a high density lipoprotein (HDL) gene that promotes the ubiquitination and degradation of liver X receptor (LXR). TTC39B null or deficient mice challenged with high fat/cholesterol/bile salt diet exhibit increased LXR protein and target gene expression. TTC39B deficiency is reported to stabilize LXR by reducing its polyubiquitination and proteasomal degradation. Hence, it reduces the incidence of atherosclerosis and steatohepatitis. TTC39B deficient mice display higher levels of HDL and apoplipoprotein A-1 and lower levels of hepatic triglyceride synthesis. However, it does not affect glucose tolerance or hepatic gluconeogenesis. (Ref.: Hsieh, J et al. (2016). Nature 535(7611): 303-307).
References
Product Information
FormatPurified
PresentationPurified rabbit polyclonal antibody in PBS with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-TTC39B, Cat. No. ABS2119, is a rabbit polyclonal antibody that detects Tetratricopeptide repeat protein 39B and has been tested for use in Western Blotting.
Key Applications
  • Western Blotting
Application NotesWestern Blotting Analysis: A representative lot detected TTC39B in cultured primary mouse hepatocytes transfected with T39 (Hsieh, J., et. al. (2016). Nature. 535(7611):303-7).
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to 20 amino acids from the C-terminal half of human Tetratricopeptide repeat protein (TTC39B).
Epitopeunknown
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityThis rabbit polyclonal antibody detects TTC39B in human and murine cells. It targets an epitope with in 20 amino acids from the C-terminal half.
IsotypeIgG
Species Reactivity
  • Mouse
  • Human
Species Reactivity NoteHuman, Mouse. Predicted to react with Rat based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • TTC39B
  • C9orf52
Purification MethodAffinity Purified
UniProt Number
Molecular Weight~90 kDa observed; 76.96 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HEK293T cells transfected with TTC39B.

Western Blotting Analysis: 1 µg/mL of this antibody detected TTC39B in 10 µg of TTC39B transfected HEK293T cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABS2119 04054839251030