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MABN2425-100UG Anti-TRPV2 Antibody, clone 17A11

Anti-TRPV2, clone 17A11, Cat. No. MABN2425, is a highly specific mouse monoclonal antibody that targets TRPV2 and has been tested for use in Immunocytochemistry and Western Blotting.

Anti-TRPV2 Antibody, clone 17A11 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: Trpv2, Sac2b, Vrl1 UniProt Number: Q9WUD2
MABN2425-100UG
100 μg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
M, RICC, WBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABN2425-100UG
DescriptionAnti-TRPV2 Antibody, clone 17A11
Alternate Names
  • Transient receptor potential cation channel subfamily V member 2
  • Osm-9-like TRP channel 2
  • OTRPC2
  • Stretch-activated channel 2B
  • Vanilloid receptor-like protein 1
  • VRL-1
Background InformationTransient receptor potential cation channel subfamily V member 2 (UniProt: Q9WUD2; also known as TrpV2, Osm-9-like TRP channel 2, OTRPC2, Stretch-activated channel 2B, Vanilloid receptor-like protein 1, VRL-1) is encoded by the Trpv2 (also known as Sac2b, Vrl1) gene (Gene ID: 29465) in rat. TrpV2 is an ubiquitously expressed, calcium-permeable, non-selective cation channel with an outward rectification. It has been implicated in various physiological and pathological processes, including growth factor signaling, macrophage migration, cancer cell metastasis, heart disease, and neuronal cell development. It appears to be regulated by growth factors, like IGF1, PDGF, and morphogenetic neuropeptide/head activator. It is also activated by temperatures higher than 52 degree C, but is not activated by vanilloids and acidic pH. TrpV2 channel is upregulated by the nerve growth factor (NGF) via the mitogen-activated protein kinase (MAPK) signaling pathway to augment neurite outgrowth. Although NGF increases TrpV2 content, it does not induce the translocation of TrpV2 from cytoplasm to cell surface in PC12 cells. (Ref.: Cohen MR., et al. (2015). Mol. Cell Biol. 35(24): 4238-4252).
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
ApplicationAnti-TRPV2, clone 17A11, Cat. No. MABN2425, is a highly specific mouse monoclonal antibody that targets TRPV2 and has been tested for use in Immunocytochemistry and Western Blotting.
Key Applications
  • Immunocytochemistry
  • Western Blotting
Application NotesWestern Blotting Analysis: A representative lot detected TRPV2 in Western Blotting applications (Cohen, M.R., et. al. (2013). PLoS One. 8(12):e85392).

Immunocytochemistry Analysis: A representative lot detected TRPV2 in Immunocytochemistry applications (Cohen, M.R., et. al. (2013). PLoS One. 8(12):e85392; Cohen M.R., et. al. (2015). Mol Cell Biol. 35(24):4238-52).
Biological Information
Immunogen1D4-tagged full length rat Transient receptor potential cation channel subfamily V member 2 (TRPV2).
Clone17A11
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone 17A11 detects Transient receptor potential cation channel subfamily V member 2 (TRPV2) in mouse and rat cells.
IsotypeIgG1κ
Species Reactivity
  • Mouse
  • Rat
Species Reactivity NoteMouse, Rat.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • Trpv2
  • Sac2b
  • Vrl1
Purification MethodProtein G purified
UniProt Number
Molecular Weight86.71 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunocytochemistry in PC12 cells treated with NGF.

Immunocytochemistry Analysis: 2-10 µg/mL of this antibody detected TRPV2 in PC12 cells treated with mouse NGF.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABN2425-100UG 04054839519512