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MABS519-AF488 Anti-P40 Antibody, clone 11F12.1, Alexa Fluor® 488

This Alexa Fluor® 488 conjugated Anti-P40 Antibody, clone 11F12.1, is validated for use in Immunocytochemistry (IHC) for the detection of P-40.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: TP63, KET, P63, P73H, P73L, TP73L UniProt Number: Q9H3D4

MABS519-AF488
100 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MICCMAlexaFluor®488Monoclonal Antibody
Description
Catalogue NumberMABS519-AF488
DescriptionAnti-P40 Antibody, clone 11F12.1, Alexa Fluor® 488
Alternate Names
  • Tumor protein 63
  • p63
  • Chronic ulcerative stomatitis protein
  • CUSP
  • Keratinocyte transcription factor KET
  • Transformation-related protein 63
  • TP63
  • Tumor protein p73-like
  • p73L
  • p40
  • p51
  • P40
Background InformationTumor protein 63 (UniProt Q9H3D4; also known as Amplified in squamous cell carcinoma, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, p40, p51, p73L, TP63, Transformation-related protein 63, Tumor protein p73-like) is encoded by the TP63 (also known as KET, P63, P73H, P73L, TP73L) gene (Gene ID 8626) in human. Tumor protein 63 is a p53 homologue that can bind p53-responsive elements to upregulate some p53 target genes and share partially overlapping functions with p53. Various functions have been ascribed to TP63 in normal squamous epithelia, including those of the esophagus and TP63 is reported to play an essential role in the maintenance of proliferative potential in epithelial stem cells. TP63 overexpression is found in various squamous epithelia carcinomas and high TP63 expression is associated with an aggressive phenotype and metastasis in many cancers.
References
Product Information
FormatAlexaFluor®488
PresentationPurified mouse conjugate antibody in PBS with 15 mg/ml BSA and 0.1 sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Alexa Fluor® 488 conjugated Anti-P40 Antibody, clone 11F12.1, is validated for use in Immunocytochemistry (IHC) for the detection of P-40.
Key Applications
  • Immunocytochemistry
Application NotesImmunocytochemistry Analysis: A 1:100 dilution from a representative lot detected P40 in HUVEC cells.
The unconjugated version (Cat. No. MABS519) has been shown to work in WB, IH(P).
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human P40 near the N-terminus.
EpitopeNear N-terminus
Clone11F12.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityExpected to react with spliced isoform 2 (DeltaN-alpha, DeltaNp63 alpha, P51delNalpha), 4 (DeltaN-beta, DeltaNp63 beta, P51delNbeta), 6 (DeltaN-gamma, DeltaNp63gamma, P51delNgamma), 8 (DeltaN-delta), 10 (DeltaN-epsilon, DeltaNp73L), 12, but not isoform 1 (TA*-alpha, TAp63alpha, P51B), 3 (TA*-beta, TAp63beta), 5 (TA*-gamma, TAp63gamma, P51A), 7 (TA*-delta, TAp63delta, P51delta), 9 (TA*-epsilon), or 11 (P63 delta).
Species Reactivity
  • Human
  • Mouse
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • TP63
  • KET
  • P63
  • P73H
  • P73L
  • TP73L
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~40 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunocytochemistry in NIH/3T3 cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected P40 in NIH/3T3 cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABS519-AF488 04055977275230