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AB1224 Anti-Myeloperoxidase Antibody, human white cell

Anti-Myeloperoxidase Antibody, human white cell is an antibody against Myeloperoxidase for use in ELISA & WB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Oxidative Stress Gene Symbol: MPO, myeloperoxidase UniProt Number: P05164
AB1224
2 mL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HELISA, WBRbSerumPolyclonal Antibody
Description
Catalogue NumberAB1224
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Myeloperoxidase Antibody, human white cell
Alternate Names
  • MPO
References
Product Information
FormatSerum
HS Code3002 15 90
PresentationMonospecific antiserum purified by delipidation and defibrination. Lyophilized from 0.02 M Potassium Phosphate buffer, 0.15 M Sodium Chloride, pH 7.2, 0.01% Sodium Azide. Reconstitute with 2.0 mL of sterile distilled water.
Quality LevelMQ100
Applications
ApplicationAnti-Myeloperoxidase Antibody, human white cell is an antibody against Myeloperoxidase for use in ELISA & WB.
Key Applications
  • ELISA
  • Western Blotting
Application NotesImmunoblotting: antibody recognizes alpha and beta subunits of MPO. Reduced and denatured extracts of purified MPO produce blots produce 55-60kDa alpha subunits and 12-14kDa beta subunit bands140 Additional bands may be present due to cross reactivity with other myeloperoxidases.

ELISA:

Optimal working dilutions must be determined by end user.
Biological Information
ImmunogenMyeloperoxidase (Human White Cells)
Epitopehuman white cell
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityMyeloperoxidase (Human White Cells). Monospecific by IEP. Some cross reactivity with Myeloperoxidase from other tissues and species may occur.

Myeloperoxidase (MPO) represents an early appearing and highly reliable intracellular myeloid lineage marker molecule. MPO protein can be detected in a subset of human hematopoietic bone marrow progenitor cells and in granulomonopoietic (GM) cells. However, other myeloid-related cell types such as epidermal Langerhans-type dendritic cells (LC) lack MPO. Therefore, human myeloid progenitors might be subdivided based on MPO protein expression into functional subsets.
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryMyeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils.
Gene Symbol
  • MPO
  • myeloperoxidase
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P05164 # Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
COFACTOR: Binds 1 calcium ion per heterodimer. & Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.
SIZE: 745 amino acids; 83869 Da
SUBUNIT: Tetramer of two light chains and two heavy chains.
SUBCELLULAR LOCATION: Lysosome.
DISEASE:SwissProt: P05164 # Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.
SIMILARITY: SwissProt: P05164 ## Belongs to the peroxidase family. XPO subfamily.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore unopened vial at 2-8 ºC. Maintain frozen at -20ºC in undiluted aliquots for up to one year after reconstitution. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size2 mL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB1224 04053252676642

Documentation

Anti-Myeloperoxidase Antibody, human white cell SDS

Title

Safety Data Sheet (SDS) 

Anti-Myeloperoxidase Antibody, human white cell Certificates of Analysis

TitleLot Number
RABBIT ANTI-MYELOPEROXIDASE (Human White Cells) POLYCLONAL ANTIBODY - 2407515 2407515
RABBIT ANTI-MYELOPEROXIDASE (Human White Cells) POLYCLONAL ANTIBODY - 2444747 2444747
RABBIT ANTI-MYELOPEROXIDASE (Human White Cells) POLYCLONAL ANTIBODY - 2445843 2445843
RABBIT ANTI-MYELOPEROXIDASE (Human White Cells) - 3671748 3671748
RABBIT ANTI-MYELOPEROXIDASE (Human White Cells) - 3873527 3873527
RABBIT ANTI-MYELOPEROXIDASE (Human White Cells) - 3884891 3884891
RABBIT ANTI-MYELOPEROXIDASE (Human White Cells) - 3994671 3994671
RABBIT ANTI-MYELOPEROXIDASE (Human White Cells) POLYCLONAL ANTIBODY 3769786
RABBIT ANTI-MYELOPEROXIDASE (Human White Cells) POLYCLONAL ANTIBODY 3032743
RABBIT ANTI-MYELOPEROXIDASE -2649221 2649221
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