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MABC967 Anti-Kallikrein 7/KLK7 Antibody, clone 73-1

Detect KLK7 using this mouse monoclonal Anti-Kallikrein 7/KLK7 Antibody, clone 73-1, Cat. No. MABC967. It was used in ELISA and Immunohistochemistry (Paraffin).

Anti-Kallikrein 7/KLK7 Antibody, clone 73-1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Gene Symbol: KLK7, PRSS6, SCCE UniProt Number: P49862
MABC967
100 μg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HELISA, IH(P)MPurifiedMonoclonal Antibody
Description
Catalogue NumberMABC967
DescriptionAnti-Kallikrein 7/KLK7 Antibody, clone 73-1
Alternate Names
  • KLK7
  • Kallikrein-7
  • hK7
  • Serine protease 6
  • Stratum corneum chymotryptic enzyme
  • hSCCE
Background InformationKallikrein-7 (UniProt: P49862; also known as hK7, Serine protease 6, Stratum corneum chymotryptic enzyme, hSCCE) is encoded by the KLK7 (also known as PRSS6, SCCE) gene (Gene ID: 5650) in human. KLK7 is a member of the 15-member kallikrein subfamily of serine proteases. Human KLK7 displays 40 60% amino acid homology with other members of the family. Members of this family are involved in diverse physiological functions and serve as biomarkers for cancer. Increased expression of KLK7 is associated with unfavorable prognosis and progression of ovarian cancer. Less differentiated tumors of more advanced stage show higher level KLK7 expression. KLK7 has chymotrypsin-like activity and cleaves proteins with aromatic side chains in the P1 position. Its activity is inhibited by Zn2+ and Cu2+. KLK7 catalyzes the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. It is also reported to play a role in the activation of precursors to inflammatory cytokines.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Sodium bicarbonate buffer, pH 8.2 with 0.02% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect KLK7 using this mouse monoclonal Anti-Kallikrein 7/KLK7 Antibody, clone 73-1, Cat. No. MABC967. It was used in ELISA and Immunohistochemistry (Paraffin).
Key Applications
  • ELISA
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Kallikrein 7/KLK7 in human kidney tissue and human bone marrow.

ELISA Analysis: A representative lot detected Kallikrein 7/KLK7 in ELISA applications (Shan, S.J., et. al. (2006). Clin Chem. 52(10):1879-86; Kishi, T., et. al. (2004). Clin Chem. 50(4):709-16).
Biological Information
ImmunogenA full length recombinant human pro-Kallikrein 7.
Clone73-1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone 73-1 specifically detects kallikrein 7 (KLK7) in human.
IsotypeIgG1κ
Species Reactivity
  • Human
Species Reactivity NoteHuman.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • KLK7
  • PRSS6
  • SCCE
UniProt Number
Molecular Weight27.53 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in human skin tissue.

Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected Kallikrein 7/KLK7 in human skin tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABC967 04054839167485