Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

ABN308 Anti-DISC1 Antibody

Anti-DISC1 detects levels of DISC1 proteins & has been published & validated for use in IHC, ICC & WB.

Anti-DISC1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: DISC1 UniProt Number: Q9NRI5
ABN308
100 µg  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, R, MIHC, ICC, WBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN308
DescriptionAnti-DISC1 Antibody
Alternate Names
  • Disrupted in schizophrenia 1
Background InformationDisrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3epsilon from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC1 has at least four known isoforms.
References
Product Information
FormatAffinity Purified
Control
  • Human brain tissue
PresentationPurified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-DISC1 detects levels of DISC1 proteins & has been published & validated for use in IHC, ICC & WB.
Key Applications
  • Immunohistochemistry
  • Immunocytochemistry
  • Western Blotting
Application NotesImmunohistochemistry Analysis: A 1:2,000 dilution of this antibody lot detected DISC1 in rat cerebellum tissue.

Immunocytochemistry Analysis: A 1:2,000 dilution from a representative lot detected DISC1 in HeLa cells.

Western Blot Analysis: 2 µg/mL from a representative lot detected DISC1 in 10 µg/mL of SK-N-SH cell lysate and mouse brain tissue lysate.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human DISC1.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
  • Rat
  • Mouse
Antibody TypePolyclonal Antibody
Gene Symbol
  • DISC1
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~94 kDa observed. Uniprot describes 8 isoforms ranging between ~39 kDa and ~94 kDa; however, there are many additional isoforms of DISC1 known to exist. (Ishizuka, K., et al. (2007). Molecular Psychiatry. 12:897-899.)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in human brain tissue.

Immunohistochemistry Analysis: A 1:2,000 dilution of this antibody lot detected DISC1 in human brain tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABN308 04053252831058