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428033 Anti-Cu2+-Oxidized Low Density Lipoprotein Rabbit pAb

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
428033
  
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Overview

Replacement Information

Key Spec Table

Host
Rb
Description
Overview

This product has been discontinued.





Recognizes both fully oxidized modifications of LDL and minimally oxidized LDL, but the reaction to native LDL is weak. Does not react with other oxidized proteins.
Catalogue Number428033
Brand Family Calbiochem®
References
ReferencesHerrick, A.L., et al. 2001. Rheumatology 40, 401.
Lau, B.H. 2001. J. Nutrition 131, 985s.
Product Information
FormLyophilized
FormulationUndiluted serum.
Applications
Key Applications Enzyme-Linked Immunosorbent Assay
Immunohistochemistry
Application NotesELISA (1:500-1:5000)
Immunohistochemistry (1:500)
Application CommentsDoes not react with other oxidized proteins. Variables associated with assay conditions will dictate the optimal working dilution.
Biological Information
Immunogenfully Cu2+-oxidized human low density lipoprotein (LDL)
ImmunogenHuman
HostRabbit
IsotypeIgG
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsReconstitute with 100 µl dH₂O. Following reconstitution, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
428033 0

Documentation

Anti-Cu2+-Oxidized Low Density Lipoprotein Rabbit pAb Certificates of Analysis

TitleLot Number
428033

References

Reference overview
Herrick, A.L., et al. 2001. Rheumatology 40, 401.
Lau, B.H. 2001. J. Nutrition 131, 985s.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-August-2008 JSW
ApplicationELISA (1:500-1:5000)
Immunohistochemistry (1:500)
DescriptionRabbit polyclonal antibody supplied as lyophilized, undiluted serum. Recognizes both fully oxidized modifications of LDL and minimally oxidized LDL, but the reaction to native LDL is weak.
BackgroundOxidation of LDL plays an important role in the initiation and progression of atherosclerosis. Arterial macrophages take up oxidized low-density lipoproteins (OxLDL), leading to cellular accumulation of cholesterol and oxysterols. OxLDL, but not native LDL, promotes vascular dysfunction by exerting direct cytotoxicity toward endothelial cells, by increasing chemotactic properties for monocytes, by transforming macrophages to foam cells via scavenger-receptors and by enhancing the proliferation of various cell types, e.g., endothelial cells, monocytes and smooth muscle cells; all of these events are recognized as contributing to atherogenesis.
HostRabbit
Immunogen speciesHuman
Immunogenfully Cu2+-oxidized human low density lipoprotein (LDL)
IsotypeIgG
Speciesa broad range of species
FormLyophilized
FormulationUndiluted serum.
CommentsDoes not react with other oxidized proteins. Variables associated with assay conditions will dictate the optimal working dilution.
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsReconstitute with 100 µl dH₂O. Following reconstitution, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesHerrick, A.L., et al. 2001. Rheumatology 40, 401.
Lau, B.H. 2001. J. Nutrition 131, 985s.