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MABN466 Anti-Ankyrin-G Antibody, clone N106/36

Anti-Ankyrin-G Antibody, clone N106/36 is a highly specific mouse monoclonal antibody & that targets Ankyrin & has been tested in IHC.

Anti-Ankyrin-G Antibody, clone N106/36 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: ANK3 UniProt Number: Q12955
MABN466
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
RIHCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABN466
DescriptionAnti-Ankyrin-G Antibody, clone N106/36
Alternate Names
  • Ankyrin-3
  • ANK-3
  • Ankyrin-G
Background InformationAnkyrins are a family of spectrin-binding proteins that couple the spectrin/actin cytoskeletal network to the cytoplasmic domains of integral membrane proteins which include channels such as the anion exchanger, voltage-dependent sodium channel, and the Na/K ATPase, as well as neuronal cell adhesion molecules related to L1. In the nervous system, three different ankyrins are known to exist; ankyrinB, ankyrinG, and ankyrinR. All three ankyrins contain an N-terminal membrane binding domain, an internal domain capable of binding spectrin, and a C-terminal regulatory domain which is the target of alternative splicing. AnkyrinB, the predominant neuronal ankyrin includes two isoforms of ~220 kDa and ~440 kDa. The ~220 kDa alternatively spliced isoform is the major form present in the adult brain, while the ~440 kDa form is preferentially expressed in the developing neonatal brain. Three forms of ankyrinG (~190 kDa, ~270 kDa, ~480 kDa) are localized in axonal initial segments and the nodes of Ranvier of myelinated axons where fluxes of action potential occur and ion channels are enriched. Ankyrins comprise ~0.5%-1% of the total membrane protein in the adult vertebrate brain.
References
Product Information
FormatPurified
Control
  • Rat hippocampus tissue
PresentationPurified mouse monoclonal IgG2aκ in 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Ankyrin-G Antibody, clone N106/36 is a highly specific mouse monoclonal antibody & that targets Ankyrin & has been tested in IHC.
Key Applications
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Ankyrin-G in rat cerebral cortex tissue.

Immunohistochemistry Analysis: A representative lot detected Ankyrin-G in rat optic nerve tissue.

Immunofluorescence Analysis: A representative lot detected Ankyrin-G in adult rat cortex tissue.

Immunofluorescence Analysis: A representative lot from an independent laboratory detected Ankyrin-G in a rat model of TLE mEC layer II neurons (Hargus, N. J., et al. (2011). Neurobiol Dis. 41(2):361-376.)
Biological Information
ImmunogenRecombinant protein corresponding to human Ankyrin-G.
CloneN106/36
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
IsotypeIgG2aκ
Species Reactivity
  • Rat
Species Reactivity NoteDemonstrated to react with Rat. Other homologies: Human (92% sequence homology), and Mouse (87% sequence homology).
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • ANK3
Purification MethodProtein G Purified
UniProt Number
Molecular Weight480 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in rat hippocampus tissue.

Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Ankyrin-G in rat hippocampus tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABN466 04053252830587

Documentation

Anti-Ankyrin-G Antibody, clone N106/36 SDS

Title

Safety Data Sheet (SDS) 

Anti-Ankyrin-G Antibody, clone N106/36 Certificates of Analysis

TitleLot Number
Anti-Ankyrin-G, clone N106/36 - 2952322 2952322
Anti-Ankyrin-G, clone N106/36 - 3213939 3213939
Anti-Ankyrin-G, clone N106/36 - 3307318 3307318
Anti-Ankyrin-G, clone N106/36 - 3324989 3324989
Anti-Ankyrin-G, clone N106/36 - 3462114 3462114
Anti-Ankyrin-G, clone N106/36 - 3503449 3503449
Anti-Ankyrin-G, clone N106/36 - 3681275 3681275
Anti-Ankyrin-G, clone N106/36 - 3743894 3743894
Anti-Ankyrin-G, clone N106/36 - 3868387 3868387
Anti-Ankyrin-G, clone N106/36 - 3879505 3879505
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