110123 Sigma-AldrichAcetyl-11-keto-β-Boswellic Acid, Boswellia serrata - CAS 67416-61-9 - Calbiochem

This product has been discontinued.

A cell-permeable pentacyclic triterpene of the ursane type that displays anti-tumor and anti-inflammatory properties. Shown to block the phosphorylation and degradation of IκBα and inhibit NF-κB-mediated gene transcription in chemoresistant, androgen-independent PC-3 prostate cancer cells (~10 µM). Mobilizes intracellular Ca²⁺ and stimulates the activation of p42/44 and p38 MAPKs (~30 µM in human PMN) and increases the formation of reactive oxygen species. Also reported to induce apoptosis and act as a non-redox, non-competitive inhibitor of 5-lipoxygenase (IC₅₀ = 1.5 µM in rat PMNLs), and topoisomerase I (≥ 10 µM in calf thymus). When complexed with γ-cyclodextrin to facilitate its delivery, AKβBA has been demonstrated to exhibit in vivo efficacy in tumor growth and inhibition.