118510 Sigma-AldrichATR Kinase Inhibitor II - Calbiochem
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Overview
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 118510-10MG | Glass bottle | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable aminopyrazinyl-sulfone compound that acts as a potent, reversible and ATP-competitive inhibitor of ATR kinase (IC50 = 12 nM; Ki = 6 nM) with excellent selectivity over ATM, DNA-PK (IC50 > 8 µM) and in a 50-kinase panel (% inhibition at 2 µM = 59, 57, 55, 52, 43 and 42 for AMPK, Lck, RIPK2, Ret, IKKα and FGFR3, respectively). Shown to block pH2AX-Ser139 (IC50 = 420 nM in hydroxyurea treated HT29 cells) and preferentially enhance cisplatin (Cat. No. 232120) cytotoxicity against tumor cells over normal cells by ~7-fold at 620 nM. |
| Catalogue Number | 118510 |
| Brand Family | Calbiochem® |
| Synonyms | 3-Amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfonyl)-phenyl)-N-phenylpyrazine-2-carboxamide |
| References | |
|---|---|
| References | Charrier, J.D., et al. 2011. J. Med. Chem. 54, 2320. |
| Product Information | |
|---|---|
| Form | Yellow powder |
| Hill Formula | C₂₂H₂₅N₅O₃S |
| Chemical formula | C₂₂H₂₅N₅O₃S |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥97% by HPLC |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 118510-10MG | 04055977223170 |