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118500 ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem

118500
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Overview

Key Spec Table

CAS #Empirical Formula
587871-26-9C₂₁H₁₇NO₃S₂

Products

Catalogue NumberPackaging Qty/Pack
118500-10MG Glass bottle 10 mg
118500-2MG Glass bottle 2 mg
Description
OverviewA cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5 , 9.3 , 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 = µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents. A 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118502) in DMSO is also available.
Catalogue Number118500
Brand Family Calbiochem®
Synonyms2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933
References
ReferencesPereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
Hickson, I., et al. 2004. Cancer Res. 64, 9152.
Product Information
CAS number587871-26-9
ATP CompetitiveY
FormWhite solid
Hill FormulaC₂₁H₁₇NO₃S₂
Chemical formulaC₂₁H₁₇NO₃S₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetATM Kinase
Primary Target IC<sub>50</sub>13 nM
Primary Target K<sub>i</sub>2.2 nM for ATM kinase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
118500-10MG 04055977224030
118500-2MG 07790788047894