208719 Sigma-AldrichALLN - CAS 110044-82-1 - Calbiochem
ALLN, CAS 110044-82-1, is a cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).
More>> ALLN, CAS 110044-82-1, is a cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Less<<ALLN - CAS 110044-82-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: LLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V
Recommended Products
Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 110044-82-1 | C₂₀H₃₇N₃O₄ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 208719-25MG | Plastic ampoule | 25 mg | |
| 208719-5MG | Plastic ampoule | 5 mg |
| Description | |
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| Overview | Cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Modulates the processing of the β-amyloid precursor protein (βAPP) to β-amyloid (Aβ). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Also inhibits reovirus-induced apoptosis in L929 cells. Inhibits the proteolysis of IκB-α and IκB-β by the ubiquitin-proteasome complex. Inhibits cell cycle progression at G1/S and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208750) in DMSO is also available. |
| Catalogue Number | 208719 |
| Brand Family | Calbiochem® |
| Synonyms | LLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V |
| Product Information | |
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| CAS number | 110044-82-1 |
| ATP Competitive | N |
| Form | White to off-white solid |
| Hill Formula | C₂₀H₃₇N₃O₄ |
| Chemical formula | C₂₀H₃₇N₃O₄ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
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| Application | ALLN, CAS 110044-82-1, is a cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). |
| Biological Information | |
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| Primary Target | Calpain-1 |
| Primary Target K<sub>i</sub> | 190 nM, 220 nM, 150 nM, 500 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Peptide Sequence | N-Acetyl-Leu-Leu-Nle-CHO |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 208719-25MG | 04055977202656 |
| 208719-5MG | 04055977202663 |
Documentation
ALLN - CAS 110044-82-1 - Calbiochem SDS
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ALLN - CAS 110044-82-1 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 208719 |
References
| Reference overview |
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| Debiasi, R.L., et al. 1999. J. Virol. 73, 695. Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966. Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388. Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721. Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229. Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67. Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353. Vinitsky, A., et al. 1992. Biochemistry 31, 9421. Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195. |
Brochure
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| Proteasomes Technical Bulletin |
Citations
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