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531726 ALDH1A1, A37 - Calbiochem

A cell permeable, selective, substrate competitive inhibitor of aldehyde dehydrogenae 1A1 (ALDH1A1; Ki = 300 nM; IC₅₀ = 4.6 µM). Does not affect the activity of other related orthologs.

ALDH1A1, A37 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: thieno[3,2-d]pyrimidin-2-yl]thio}acetate, Acetaldehyde Dehydrogenase 1A1 inhibitor, A37

Primary Target: ALDH1A1
531726
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₁H₂₅N₃O₃S₂
Description
Overview

This product has been discontinued.



A cell permeable benzothieno[3,2-d]pyrimidone derivative that acts as a selective, substrate competitive inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1; Ki = 300 nM; IC50 = 4.6 µM) in ovarian cancer spheroids. Does not affect the activity of other related orthologs, including ALDH1A2, ALDH1A3, ALDH2 and ALDH3A1 even at higher concentrations (> 100 µM). Enhances sensitization of IGROV1 ovarian carcinoma cells to cisplatin. Disrupts spheroid formation and reduces viability of ovarian cancer cells.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Catalogue Number531726
Brand Family Calbiochem®
Synonymsthieno[3,2-d]pyrimidin-2-yl]thio}acetate, Acetaldehyde Dehydrogenase 1A1 inhibitor, A37
References
ReferencesCondello, S., et al. 2014. Oncogene. 33, in press.
Product Information
FormOff-white solid
Hill FormulaC₂₁H₂₅N₃O₃S₂
Chemical formulaC₂₁H₂₅N₃O₃S₂
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetALDH1A1
Primary Target IC<sub>50</sub>4.6 µM
Primary Target K<sub>i</sub>300 nM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
531726 0

Documentation

ALDH1A1, A37 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Condello, S., et al. 2014. Oncogene. 33, in press.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-March-2015 JSW
Synonymsthieno[3,2-d]pyrimidin-2-yl]thio}acetate, Acetaldehyde Dehydrogenase 1A1 inhibitor, A37
DescriptionA cell permeable benzothieno[3,2-d]pyrimidone derivative that acts as a selective, substrate competitive inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1; Ki = 300 nM; IC50 = 4.6 µM) in ovarian cancer spheroids. Does not affect the activity of other related orthologs, including ALDH1A2, ALDH1A3, ALDH2 and ALDH3A1 even at higher concentrations (> 100 µM). Enhances sensitization of IGROV1 ovarian carcinoma cells to cisplatin. Disrupts spheroid formation and reduces viability of ovarian cancer cells.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₁H₂₅N₃O₃S₂
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesCondello, S., et al. 2014. Oncogene. 33, in press.