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658400 AG 82 - CAS 118409-58-8 - Calbiochem

A cell-permeable, reversible, and competitive inhibitor of substrate binding on protein tyrosine kinases.

AG 82 - CAS 118409-58-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-Cyano-(3,4,5-trihydroxy)cinnamonitrile, Tyrphostin A25

Primary Target: epidermal growth factor receptor tyrosine kinase
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
118409-58-8C₁₀H₆N₂O₃
Description
Overview

This product has been discontinued.



A cell-permeable, reversible, and competitive inhibitor of substrate binding on protein tyrosine kinases. Inhibits epidermal growth factor receptor tyrosine kinase (IC50 = 3 µM) and the GTPase activity of transducin (IC50 = 7 µM). Inhibits neuromedin B-induced phosphorylation of p125FAK (focal adhesion kinase). Blocks the induction of inducible nitric oxide synthase in glial cells. Induces apoptosis in human leukemic cell lines.
Catalogue Number658400
Brand Family Calbiochem®
Synonymsα-Cyano-(3,4,5-trihydroxy)cinnamonitrile, Tyrphostin A25
References
ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
Tsuda, T., et al. 1997. Biochemistry 36, 16328.
Wolbring, G., et al. 1994. J. Biol. Chem. 269, 22470.
Bergamaschi, G., et al. 1993. Leukemia 7, 2012.
Piontek, M., et al. 1993. Anticancer Res. 13, 2119.
Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721.
Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
Yaish, P., et al. 1988. Science 242, 933.
Product Information
CAS number118409-58-8
ATP CompetitiveY
FormDark yellow solid
Hill FormulaC₁₀H₆N₂O₃
Chemical formulaC₁₀H₆N₂O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetepidermal growth factor receptor tyrosine kinase
Primary Target IC<sub>50</sub>3 µM against epidermal growth factor receptor tyrosine kinase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
658400 0

Documentation

AG 82 - CAS 118409-58-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

AG 82 - CAS 118409-58-8 - Calbiochem Certificates of Analysis

TitleLot Number
658400

References

Reference overview
Jaleel, M., et al. 2004. Biochemistry 43, 8247.
Tsuda, T., et al. 1997. Biochemistry 36, 16328.
Wolbring, G., et al. 1994. J. Biol. Chem. 269, 22470.
Bergamaschi, G., et al. 1993. Leukemia 7, 2012.
Piontek, M., et al. 1993. Anticancer Res. 13, 2119.
Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721.
Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
Yaish, P., et al. 1988. Science 242, 933.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-January-2010 RFH
Synonymsα-Cyano-(3,4,5-trihydroxy)cinnamonitrile, Tyrphostin A25
DescriptionA cell-permeable, reversible, and competitive inhibitor of substrate binding on protein tyrosine kinases. Inhibits epidermal growth factor receptor tyrosine kinase (IC50 = 3 µM) and the GTPase activity of transducin (IC50 = 7 µM). Blocks the induction of inducible nitric oxide synthase in glial cells. Induces apoptosis in human leukemic cell lines. Also reported to inhibit guanylyl cyclase.
FormDark yellow solid
CAS number118409-58-8
Chemical formulaC₁₀H₆N₂O₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml) or Methanol (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
Tsuda, T., et al. 1997. Biochemistry 36, 16328.
Wolbring, G., et al. 1994. J. Biol. Chem. 269, 22470.
Bergamaschi, G., et al. 1993. Leukemia 7, 2012.
Piontek, M., et al. 1993. Anticancer Res. 13, 2119.
Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721.
Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
Yaish, P., et al. 1988. Science 242, 933.