Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

100105 A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem

A mobile ion-carrier that forms stable complexes with divalent cations.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Calcimycin

100105
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
52665-69-7C₂₉H₃₇N₃O₆

Products

Catalogue NumberPackaging Qty/Pack
100105-10MG Plastic ampoule 10 mg
100105-1MG Plastic ampoule 1 mg
100105-5MG Plastic ampoule 5 mg
Description
OverviewA mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
Catalogue Number100105
Brand Family Calbiochem®
SynonymsCalcimycin
References
ReferencesCaron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.
Product Information
CAS number52665-69-7
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₉H₃₇N₃O₆
Chemical formulaC₂₉H₃₇N₃O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMitochondrial ATPase
Purity≥98% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSDM4676000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
100105-10MG 04055977226232
100105-1MG 04055977226225
100105-5MG 04055977226249

Documentation

A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem Certificates of Analysis

TitleLot Number
100105

References

Reference overview
Caron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2008 RFH
SynonymsCalcimycin
DescriptionA mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
FormWhite solid
CAS number52665-69-7
RTECSDM4676000
Chemical formulaC₂₉H₃₇N₃O₆
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO or Methanol. For use in aqueous systems, preparation of a 100 mM stock in DMSO is recommended. Microliter amounts of this solution can then be added to H₂O with rapid mixing (e.g. 10 µl into 5 ml of H₂O). In aqueous systems, the ionophore aggregates over time.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity Standard Handling
Merck USA index14, 1639
ReferencesCaron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.

Related Products & Applications

Alternative Products

Catalogue Number Description
100106 A23187, Mixed Calcium-Magnesium Salt - CAS 52665-69-7 - Calbiochem
100107 A23187, 4-Bromo- - CAS 76455-48-6 - Calbiochem

Related Products

Catalogue Number Description
407950 Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem
676377 Valinomycin, Streptomyces fulvissimus - CAS 2001-95-8 - Calbiochem

Categories

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Ionophores