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483400 7-Nitroindazole - CAS 2942-42-9 - Calbiochem

A cell-permeable, reversible and competitive inhibitor of nitric oxide synthase (NOS) with high selectivity for the brain enzyme (IC₅₀ = 710 nM) vs.

7-Nitroindazole - CAS 2942-42-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7-Ni

Primary Target: NOS
483400
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
2942-42-9C₇H₅N₃O₂
Description
Overview

This product has been discontinued.



A cell-permeable, reversible and competitive inhibitor of nitric oxide synthase (NOS) with high selectivity for the brain enzyme (IC50 = 710 nM) vs. iNOS (IC50 = 20 µM). Also inhibits bovine endothelial nitric oxide synthase (IC50 = 800 nM). Binds to the heme group of NOS.
Catalogue Number483400
Brand Family Calbiochem®
Synonyms7-Ni
References
ReferencesSchulz, J.B., et al. 1995. J. Neurochem. 64, 936.
Klatt, P., et al. 1994. J. Biol. Chem. 269, 13861.
Wolff, D.J., et al. 1994. Arch. Biochem. Biophys. 314, 360.
Babbedge, R.C., et al. 1993. Br. J. Pharmacol. 110, 225.
Moore, P.K., et al. 1993. Br. J. Pharmacol. 108, 296.
Product Information
CAS number2942-42-9
ATP CompetitiveY
FormYellowish brown solid
Hill FormulaC₇H₅N₃O₂
Chemical formulaC₇H₅N₃O₂
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetNOS
Primary Target IC<sub>50</sub>710 nM against the brain enzyme nitric oxide synthase (NOS)
Purity≥97% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSNK7962200
Safety Information
R PhraseR: 40-60

Limited evidence of a carcinogenic effect.
May impair fertility.
S PhraseS: 53-22-36/37/39-45

Avoid exposure - obtain special instructions before use.
Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


From Catalog:
Desc. Field- added "cell-permeable
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
483400 0

Documentation

7-Nitroindazole - CAS 2942-42-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

7-Nitroindazole - CAS 2942-42-9 - Calbiochem Certificates of Analysis

TitleLot Number
483400

References

Reference overview
Schulz, J.B., et al. 1995. J. Neurochem. 64, 936.
Klatt, P., et al. 1994. J. Biol. Chem. 269, 13861.
Wolff, D.J., et al. 1994. Arch. Biochem. Biophys. 314, 360.
Babbedge, R.C., et al. 1993. Br. J. Pharmacol. 110, 225.
Moore, P.K., et al. 1993. Br. J. Pharmacol. 108, 296.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-August-2008 RFH
Synonyms7-Ni
DescriptionA reversible and competitive inhibitor of nitric oxide synthase (NOS) with high selectivity for the brain enzyme (IC50 = 710 nM). Also inhibits bovine endothelial nitric oxide synthase (IC50 = 800 nM). Binds to the heme group of NOS.
FormYellowish brown solid
CAS number2942-42-9
RTECSNK7962200
Chemical formulaC₇H₅N₃O₂
Structure formulaStructure formula
Purity≥97% by TLC
SolubilityDMSO (50 mg/ml) or Methanol (5 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


From Catalog:
Desc. Field- added "cell-permeable
Toxicity Carcinogenic / Teratogenic
ReferencesSchulz, J.B., et al. 1995. J. Neurochem. 64, 936.
Klatt, P., et al. 1994. J. Biol. Chem. 269, 13861.
Wolff, D.J., et al. 1994. Arch. Biochem. Biophys. 314, 360.
Babbedge, R.C., et al. 1993. Br. J. Pharmacol. 110, 225.
Moore, P.K., et al. 1993. Br. J. Pharmacol. 108, 296.