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505736 5-BDBD - CAS 768404-03-1 - Calbiochem

5-BDBD - CAS 768404-03-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-(3-Bromophenyl)-1,3-dihydro-2H-Benzofuro[3,2-e]-1,4-diazepin-2-one, P2X4 Purinergic Receptor Antagonist, 5-BDBD

Primary Target: P2X₄
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
768404-03-1C₁₇H₁₁BrN₂O₂
Description
Overview

This product has been discontinued.



A highly potent antagonist of purinergic P2X4 receptor. Shown to block P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 500 nM). Blocks ATP-induced dilation of spiral ligament capillaries in guinea pigs. Also shown to restore the viability of activated CD4+ cells in the presence of 1 mM ATP.
Catalogue Number505736
Brand Family Calbiochem®
Synonyms5-(3-Bromophenyl)-1,3-dihydro-2H-Benzofuro[3,2-e]-1,4-diazepin-2-one, P2X4 Purinergic Receptor Antagonist, 5-BDBD
References
ReferencesTrabanelli, S., et al. 2012. J. Immunol. 189, 1303.
Wu, T., et al. 2011. Am. J. Physiol. 301, H69.
Product Information
CAS number 768404-03-1
FormOff-white powder
Hill FormulaC₁₇H₁₁BrN₂O₂
Chemical formulaC₁₇H₁₁BrN₂O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetP2X₄
Primary Target IC<sub>50</sub>500 nM
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
505736 0

Documentation

5-BDBD - CAS 768404-03-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Trabanelli, S., et al. 2012. J. Immunol. 189, 1303.
Wu, T., et al. 2011. Am. J. Physiol. 301, H69.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-September-2013 JSW
Synonyms5-(3-Bromophenyl)-1,3-dihydro-2H-Benzofuro[3,2-e]-1,4-diazepin-2-one, P2X4 Purinergic Receptor Antagonist, 5-BDBD
DescriptionA highly potent antagonist of purinergic P2X4 receptor. Shown to block P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 500 nM). Blocks ATP-induced dilation of spiral ligament capillaries in guinea pigs. Also shown to restore the viability of activated CD4+ cells in the presence of 1 mM ATP.
FormOff-white powder
CAS number 768404-03-1
Chemical formulaC₁₇H₁₁BrN₂O₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (15 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTrabanelli, S., et al. 2012. J. Immunol. 189, 1303.
Wu, T., et al. 2011. Am. J. Physiol. 301, H69.