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505736 5-BDBD - CAS 768404-03-1 - Calbiochem

5-BDBD - CAS 768404-03-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-(3-Bromophenyl)-1,3-dihydro-2H-Benzofuro[3,2-e]-1,4-diazepin-2-one, P2X4 Purinergic Receptor Antagonist, 5-BDBD

Primary Target: P2X₄
505736
  
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Overview

Key Spec Table

CAS #Empirical Formula
768404-03-1C₁₇H₁₁BrN₂O₂
Description
Overview

This product has been discontinued.



A highly potent antagonist of purinergic P2X4 receptor. Shown to block P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 500 nM). Blocks ATP-induced dilation of spiral ligament capillaries in guinea pigs. Also shown to restore the viability of activated CD4+ cells in the presence of 1 mM ATP.
Catalogue Number505736
Brand Family Calbiochem®
Synonyms5-(3-Bromophenyl)-1,3-dihydro-2H-Benzofuro[3,2-e]-1,4-diazepin-2-one, P2X4 Purinergic Receptor Antagonist, 5-BDBD
References
ReferencesTrabanelli, S., et al. 2012. J. Immunol. 189, 1303.
Wu, T., et al. 2011. Am. J. Physiol. 301, H69.
Product Information
CAS number 768404-03-1
FormOff-white powder
Hill FormulaC₁₇H₁₁BrN₂O₂
Chemical formulaC₁₇H₁₁BrN₂O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetP2X₄
Primary Target IC<sub>50</sub>500 nM
Purity≥99% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
505736 0