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390900 4-Hydroxyphenylretinamide - CAS 65646-68-6 - Calbiochem

A synthetic amide of all-trans retinoic acid (RA) that displays reduced toxicity relative to RA while maintaining significant biological activity.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Fenretinide, 4HPR, N-(4-Hydroxyphenyl)-all-trans Retinamide

Primary Target: Active in the prevention and treatment of a variety of neoplasms in animals.
390900
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
65646-68-6C₂₆H₃₃NO₂

Products

Catalogue NumberPackaging Qty/Pack
390900-5MG Plastic ampoule 5 mg
Description
OverviewA synthetic amide of all-trans retinoic acid (RA) that displays reduced toxicity relative to RA while maintaining significant biological activity. Active in the prevention and treatment of a variety of neoplasms in animals. Inhibits human breast cancer, prostate adenocarcinoma, and ovarian carcinoma cell proliferation. Inhibits angiogenesis as well as endothelial cell motility and tubule formation. Induces apoptosis in malignant hemopoietic cell lines.
Catalogue Number390900
Brand Family Calbiochem®
SynonymsFenretinide, 4HPR, N-(4-Hydroxyphenyl)-all-trans Retinamide
References
ReferencesFormelli, F., et al. 1996. FASEB J. 10, 1014.
Naik, H.R., et al. 1995. Adv. Pharmacol. 33, 315.
Delia, D., et al. 1993. Cancer Res. 53, 6036.
Pienta, K.J., et al. 1993. Cancer Res. 53, 224.
Grubbs, C.J., et al. 1990. Anticancer Res. 10, 661.
McCarthy, D.J., et al. 1987. Cancer Res. 47, 5014.
Moon, R.C., et al. 1979. Cancer Res. 39, 1339.
Product Information
CAS number65646-68-6
ATP CompetitiveN
FormOrange solid
Hill FormulaC₂₆H₃₃NO₂
Chemical formulaC₂₆H₃₃NO₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetActive in the prevention and treatment of a variety of neoplasms in animals.
Purity≥97% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSVH6420000
Safety Information
R PhraseR: 20/21/22-36/37/38-60-61

Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
May impair fertility.
May cause harm to the unborn child.
S PhraseS: 26-36/37/39-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
390900-5MG 04055977190007

Documentation

4-Hydroxyphenylretinamide - CAS 65646-68-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

4-Hydroxyphenylretinamide - CAS 65646-68-6 - Calbiochem Certificates of Analysis

TitleLot Number
390900

References

Reference overview
Formelli, F., et al. 1996. FASEB J. 10, 1014.
Naik, H.R., et al. 1995. Adv. Pharmacol. 33, 315.
Delia, D., et al. 1993. Cancer Res. 53, 6036.
Pienta, K.J., et al. 1993. Cancer Res. 53, 224.
Grubbs, C.J., et al. 1990. Anticancer Res. 10, 661.
McCarthy, D.J., et al. 1987. Cancer Res. 47, 5014.
Moon, R.C., et al. 1979. Cancer Res. 39, 1339.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-March-2008 JSW
SynonymsFenretinide, 4HPR, N-(4-Hydroxyphenyl)-all-trans Retinamide
DescriptionA synthetic amide of all-trans retinoic acid (RA) that displays reduced toxicity relative to RA while maintaining significant biological activity. Active in the prevention and treatment of a variety of neoplasms in animals. Inhibits proliferation in cell lines of human breast cancer, prostate adenocarcinoma, and ovarian carcinoma. Inhibits angiogenesis, as well as endothelial cell motility and tubule formation. Induces apoptosis in malignant hemopoietic cell lines.
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number65646-68-6
RTECSVH6420000
Chemical formulaC₂₆H₃₃NO₂
Structure formulaStructure formula
Purity≥97% by TLC
SolubilityAcetone, DMSO (25 mg/ml), or Ethanol
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
Merck USA index14, 3998
ReferencesFormelli, F., et al. 1996. FASEB J. 10, 1014.
Naik, H.R., et al. 1995. Adv. Pharmacol. 33, 315.
Delia, D., et al. 1993. Cancer Res. 53, 6036.
Pienta, K.J., et al. 1993. Cancer Res. 53, 224.
Grubbs, C.J., et al. 1990. Anticancer Res. 10, 661.
McCarthy, D.J., et al. 1987. Cancer Res. 47, 5014.
Moon, R.C., et al. 1979. Cancer Res. 39, 1339.