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565764 γ-Secretase Substrate, Fluorogenic - Calbiochem

565764
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Overview

Products

Catalogue NumberPackaging Qty/Pack
565764-1MG Plastic ampoule 1 mg
Description
OverviewAn internally quenched fluorogenic peptide substrate containing the C-terminal β-APP (amyloid β-peptide precursor protein) amino acid sequence that is cleaved by γ-secretase. Shown to be sensitive and useful for assaying γ-secretase activity. The proteolysis at the Aβ40-, Aβ42-, and Aβ43-generating cleavage sites results in enhanced fluorescence.
Catalogue Number565764
Brand Family Calbiochem®
SynonymsNMA-GGVVIATVK(DNP)-DRDRDR-NH₂
References
ReferencesFarmery, M.R., et al. 2003. J. Biol. Chem. 278, 24277.
Product Information
ATP CompetitiveN
FormYellow Lyophilized
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₇₀H₁₁₆N₂₆O₁₈
Chemical formulaC₇₀H₁₁₆N₂₆O₁₈
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Biological Information
Primary Targetγ-secretase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceNMA-Gly-Gly-Val-Val-Ile-Ala-Thr-Val-Lys(DNP)-D-Arg-D-Arg-D-Arg-NH₂
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, flush with a stream of inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
565764-1MG 04055977267730