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537075 (±)-Propranolol, Hydrochloride - CAS 3506-09-0 - Calbiochem

A highly lipophilic agent that blocks both β₁ and β₂ adrenergic receptors with equal potency.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (±)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol, HCl

Primary Target: β1 and β2 adrenergic receptors
537075
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
3506-09-0C₁₆H₂₁NO₂ · HCl
Description
OverviewA highly lipophilic agent that blocks both β1 and β2 adrenergic receptors with equal potency. Has no effect on α-adrenergic receptors. Also binds to 5HT-1B receptors with high affinity (Ki = 17 nM) in contrast to 5HT-1D receptors (Ki = 10.2 µM). Readily enters the central nervous system. Blocks phospholipase D-derived diacylglycerol (DAG) formation by inhibiting phosphatidate phosphohydrolase. Useful tool for discriminating between phospholipase D- or phospholipase C-mediated DAG production. An anti-hypertensive agent that is also used in the treatment of cardiac arrhythmias.
Catalogue Number537075
Brand Family Calbiochem®
Synonyms(±)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol, HCl
References
ReferencesFujita, K., et al. 1996. FEBS Lett. 395, 293.
Glennon, R.A., et al. 1996. Mol. Pharmacol. 49, 198.
Thompson, N.T., et al. 1991. Trends Pharmacol. Sci. 12, 404.
Hoffman, B.B., and Lefkowitz, R.J. 1990. in The Pharmacological Basis of Therapeutics (Gilman, A.G., et al., Eds.) p. 221, Pergamon Press, New York.
Product Information
CAS number3506-09-0
ATP CompetitiveN
FormWhite powder
Hill FormulaC₁₆H₂₁NO₂ · HCl
Chemical formulaC₁₆H₂₁NO₂ · HCl
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetβ1 and β2 adrenergic receptors
Primary Target K<sub>i</sub>17 nM for 5HT-1B receptors
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSUB7526000
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
537075 0

Documentation

(±)-Propranolol, Hydrochloride - CAS 3506-09-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

(±)-Propranolol, Hydrochloride - CAS 3506-09-0 - Calbiochem Certificates of Analysis

TitleLot Number
537075

References

Reference overview
Fujita, K., et al. 1996. FEBS Lett. 395, 293.
Glennon, R.A., et al. 1996. Mol. Pharmacol. 49, 198.
Thompson, N.T., et al. 1991. Trends Pharmacol. Sci. 12, 404.
Hoffman, B.B., and Lefkowitz, R.J. 1990. in The Pharmacological Basis of Therapeutics (Gilman, A.G., et al., Eds.) p. 221, Pergamon Press, New York.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-August-2017 JSW
Synonyms(±)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol, HCl
DescriptionA highly lipophilic β-adrenergic blocker. Blocks both β1 and β2 receptors with equal potency. Has no effect on a-adrenergic receptors. Also binds to 5HT-1B receptors with high affinity (Ki = 17 nM) in contrast to 5HT-1D receptors (Ki = 10.2 µM). Readily enters the central nervous system. Blocks phospholipase D-derived diacylglycerol (DAG) formation by inhibiting phosphatidate phosphohydrolase. Useful tool for discriminating between phospholipase D or phospholipase C mediated DAG production. An antihypertensive agent that is also used in the treatment of cardiac arrhythmias.
FormWhite powder
CAS number3506-09-0
RTECSUB7526000
Chemical formulaC₁₆H₂₁NO₂ · HCl
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityMethanol or H₂O
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Toxicity Harmful
Merck USA index14, 7840
ReferencesFujita, K., et al. 1996. FEBS Lett. 395, 293.
Glennon, R.A., et al. 1996. Mol. Pharmacol. 49, 198.
Thompson, N.T., et al. 1991. Trends Pharmacol. Sci. 12, 404.
Hoffman, B.B., and Lefkowitz, R.J. 1990. in The Pharmacological Basis of Therapeutics (Gilman, A.G., et al., Eds.) p. 221, Pergamon Press, New York.