Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

475878 (+)-MK 801 Maleate - CAS 77086-22-7 - Calbiochem

A highly potent, selective, and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA-associated ion channel, thus preventing Ca2+ flux.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-10-imine, Maleate, Dizocilpine Maleate, NMDA Antagonist I

Primary Target: NMDA receptor
475878
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
77086-22-7C₁₆H₁₅N · C₄H₄O₄
Description
OverviewA highly potent, selective, and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA-associated ion channel, thus preventing Ca2+ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca2+ entry induced seizures.
Catalogue Number475878
Brand Family Calbiochem®
Synonyms(5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-10-imine, Maleate, Dizocilpine Maleate, NMDA Antagonist I
References
ReferencesIkonomidou, C., et al. 1999. Science 283, 70.
DeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
Woodruff, G.N., et al. 1987. Neuropharmacology 26, 903.
Wong, E.H.F., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 7104.
Product Information
CAS number77086-22-7
FormWhite solid
Hill FormulaC₁₆H₁₅N · C₄H₄O₄
Chemical formulaC₁₆H₁₅N · C₄H₄O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNMDA receptor
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in water refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Aqueous stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
475878 0

Documentation

(+)-MK 801 Maleate - CAS 77086-22-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

(+)-MK 801 Maleate - CAS 77086-22-7 - Calbiochem Certificates of Analysis

TitleLot Number
475878

References

Reference overview
Ikonomidou, C., et al. 1999. Science 283, 70.
DeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
Woodruff, G.N., et al. 1987. Neuropharmacology 26, 903.
Wong, E.H.F., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 7104.

Brochure

Title
Excitotoxic Glutamate Analogs Technical Bulletin
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-January-2010 JSW
Synonyms(5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-10-imine, Maleate, Dizocilpine Maleate, NMDA Antagonist I
DescriptionA highly potent, selective and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA associated ion channel, preventing Ca2+ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca2+ entry induced seizures.
FormWhite solid
CAS number77086-22-7
Chemical formulaC₁₆H₁₅N · C₄H₄O₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityEthanol or H₂O (3 mg/ml). Stock solutions in water may require warming and vigorous stirring to achieve complete solubilization.
Storage Protect from moisture
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution in water refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Aqueous stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
Toxicity Standard Handling
Merck USA index14, 3386
ReferencesIkonomidou, C., et al. 1999. Science 283, 70.
DeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
Woodruff, G.N., et al. 1987. Neuropharmacology 26, 903.
Wong, E.H.F., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 7104.