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196878 (±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem

Synthetic dihydropyridine derivative that acts as an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types.

(±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester

Primary Target: L-type Ca2+ channel
196878
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
93468-89-4C₁₆H₁₅F₃N₂O₄

Products

Catalogue NumberPackaging Qty/Pack
196878-1MG Plastic ampoule 1 mg
196878-5MG Plastic ampoule 5 mg
Description
OverviewSynthetic dihydropyridine derivative that acts as an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca2+ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive inotropic, and Ca2+ agonistic properties, whereas the (+)-enantiomer has weakly vasodilating, negative inotropic, and Ca2+ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.
Catalogue Number196878
Brand Family Calbiochem®
Synonyms1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester
References
ReferencesWang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
Tagliatela, M., et al. 1986. Brain Res. 381, 356.
Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.
Product Information
CAS number93468-89-4
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₆H₁₅F₃N₂O₄
Chemical formulaC₁₆H₁₅F₃N₂O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetL-type Ca2+ channel
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
196878-1MG 04055977206609
196878-5MG 04055977206616

Documentation

(±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

(±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem Certificates of Analysis

TitleLot Number
196878

References

Reference overview
Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
Tagliatela, M., et al. 1986. Brain Res. 381, 356.
Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision02-February-2009 JSW
Synonyms1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester
DescriptionA synthetic dihydropyridine derivative that is an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid, and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca2+ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive ionotropic, and Ca2+ agonistic properties, whereas the (+)-enantiomer has weak vasodilating, negative ionotropic, and Ca2+ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.
FormYellow solid
CAS number93468-89-4
Chemical formulaC₁₆H₁₅F₃N₂O₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityEthanol (35 mg/ml) or DMSO (35 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.
Toxicity Irritant
ReferencesWang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
Tagliatela, M., et al. 1986. Brain Res. 381, 356.
Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.