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565740 α-Amyloid Precursor Protein Modulator - CAS 497259-23-1 - Calbiochem

A cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam, PKC Activator V

Primary Target: PKC
565740
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
497259-23-1C₂₇H₃₀F₃N₃O₃

Products

Catalogue NumberPackaging Qty/Pack
565740-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. Displays a marked loss of tumor promoting activity.
Catalogue Number565740
Brand Family Calbiochem®
Synonyms(2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam, PKC Activator V
References
ReferencesKozikowski, A.P., et al. 2003. J. Med. Chem. 46, 364.
Product Information
CAS number497259-23-1
ATP CompetitiveN
FormOrange solid
Hill FormulaC₂₇H₃₀F₃N₃O₃
Chemical formulaC₂₇H₃₀F₃N₃O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKC
Primary Target K<sub>i</sub>11.9 nM for activating PKCα
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
565740-1MG 04055977267648

Documentation

α-Amyloid Precursor Protein Modulator - CAS 497259-23-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

α-Amyloid Precursor Protein Modulator - CAS 497259-23-1 - Calbiochem Certificates of Analysis

TitleLot Number
565740

References

Reference overview
Kozikowski, A.P., et al. 2003. J. Med. Chem. 46, 364.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-September-2010 JSW
Synonyms(2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam, PKC Activator V
DescriptionA cell-permeable PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) but lacks any tumor promoting activity.
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number497259-23-1
Chemical formulaC₂₇H₃₀F₃N₃O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml) or Methanol (1 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKozikowski, A.P., et al. 2003. J. Med. Chem. 46, 364.