Operator Certification for Tangential
Flow Filtration Module Maintenance
Two-Day Course
Course Description
Using a combination of theory and hands-on instruction, you will learn the key tangential flow filtration (TFF) procedures to increase process efficiency, quality and consistency as well as to ensure reproducible TFF separation. This two-day course covers the central elements of TFF maintenance including installation, sanitization and integrity testing. Post-TFF procedures such as cleaning, cleaning assessments and storage are also highlighted.
Course ID: TRTFF02
Dates & Venue
Course Content
- Ensuring reproducible performance of TFF modules
- Avoiding yield losses and increasing production efficiency
- Maintaining module longevity
- Maintaining microbial control of modules during storage
Hands-on practical section:
- Perform manual and automatic integrity testing of tangential flow filtration modules
- Perform standard cleaning procedures
- Measure normalized water permeability (NWP)
- Troubleshoot, using real case studies
Learning Goals
- Explain the steps required to maintain TFF modules using industry best practices
- Evaluate filter-flushing effectiveness
- Conduct integrity testing to evaluate the integrity of the TFF system
- Take manual normalized water permeability (NWP) measurements to determine cleaning effectiveness
- Choose and implement a cleaning protocol based on the type of TFF membrane module and sample composition
- Identify TFF module replacement criteria
- Collect essential data and calculate important TFF module maintenance performance criteria
- Apply troubleshooting guidelines
Who should attend?
- The course is designed primarily for production quality or validation personnel who are responsible for TFF processes in pharmaceutical and biopharmaceutical production operations.
What will you receive?
- A copy of the course materials
- A certificate of successful completion. The assessment comes from the results of the workshop and a practical quiz.
Course Schedule and Program
Day 1: 08.30 – 17.30
- Welcome and course introduction
- Introduction to TFF
- Basic TFF operation
- Practical session - installing and flushing modules
- Integrity-testing TFF modules
- Cleaning TFF modules and practical applications
- Method to determine cleaning effectiveness
- Practical session - measuring integrity and NWP
Day 2: 08.30 – 15.45
- Practical session - cleaning and NWP troubleshooting exercise
- Practical certification for integrity and NWP measurements
- Demonstration - automatic integrity test
- Integrity-testing troubleshooting exercises
- Certification and conclusion
Enrollment Limited to 10 Participants
Due to the hands-on nature of this course, enrollment is limited to 10. We recommend early booking to ensure a place.
Price
Please contact your local representative or email ilearn@merckgroup.com for a quote.